76327-08-7Relevant academic research and scientific papers
Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat
Bi, Wei,Bi, Yue,Xue, Ping,Zhang, Yanrong,Gao, Xiang,Wang, Zhibo,Li, Meng,Baudy-Floc'H, Michele,Ngerebara, Nathaniel,Li, Xiaoxu,Gibson, K. Michael,Bi, Lanrong
experimental part, p. 2441 - 2452 (2011/06/21)
We have synthesized a series of new β-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick ass
Efficient synthesis of 2,5-diketopiperazines using microwave assisted heating
Tullberg, Marcus,Gr?tli, Morten,Luthman, Kristina
, p. 7484 - 7491 (2007/10/03)
In this study a general, efficient and environmentally benign solution phase synthesis of 2,5-diketopiperazines (DKPs) using microwave assisted heating in water is described. A series of 11 structurally different DKPs have been synthesized from dipeptide methyl esters. A range of common laboratory solvents have been tested as well as different reaction times and temperatures. Both classic thermal and microwave assisted heating have been investigated. Microwave assisted heating for 10 min using water as solvent proved, by far, to be the most efficient method of cyclization giving moderate to excellent yields (63-97%) of DKPs. In contrast to other published procedures, this method seems independent of the amino acid sequence.
Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists
Hagiwara,Miyake,Morimoto,Murai,Fujii,Matsuo
, p. 2015 - 2025 (2007/10/02)
To discover a novel and low molecular weight substance P (SP) antagonist we postulated that the essential binding domain of peptide ligands was only a small portion in the whole structure. On the basis of this assumption, we selected the known octapeptide
