76336-95-3

Usage

Uses

Used in Pharmaceutical Industry:
[3-(4-nitrophenyl)aziridin-2-yl](phenyl)methanone is used as a potential anticancer agent for its ability to covalently bind to biomolecules, which may lead to the development of novel cancer treatments.
Used in Antimicrobial Applications:
In the field of antimicrobials, [3-(4-nitrophenyl)aziridin-2-yl](phenyl)methanone is used as a compound with potential to combat various microorganisms due to its reactive nature and ability to interact with biological targets.
Further research is required to fully understand the compound's mechanism of action and its potential applications in these areas.

Upstream product

• 1222-98-6 4-nitrochalcone 
• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 555-16-8 4-nitrobenzaldehdye 
• 98-86-2 acetophenone 
• 38895-96-4 p-nitrochalcone dibromide 
• 101855-05-4 3-Methoxyamino-3-(4-nitro-phenyl)-1-phenyl-propan-1-one 
• 24213-17-0 (trans)-2,3-dibromo-3-(4-nitrophenyl)-1-phenylpropan-1-one 

Downstream Products

• 128730-72-3 N-[(2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carbothioyl]-4-bromo-benzamide 
• 109831-10-9 1-(4-Chlorphenylcarbamoyl)-2-(4-nitrophenyl)-3-benzoylaziridin 
• 128730-70-1 N-[(2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carbothioyl]-4-fluoro-benzamide 
• 109831-08-5 (2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carboxylic acid phenylamide 
• 128730-74-5 N-[(2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carbothioyl]-benzamide 
• 128730-71-2 N-[(2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carbothioyl]-4-chloro-benzamide 
• 128730-73-4 N-[(2R,3S)-2-Benzoyl-3-(4-nitro-phenyl)-aziridine-1-carbothioyl]-4-nitro-benzamide 
• 13591-65-6 2,2-dimethyl-6-(4-nitrophenyl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene 
• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis of new pyrazolyl-1,3-diazabicyclo[3.1.0]hexe-3-ene derivatives

A series of new of photochromic 1,3-diazabicyclo[3.1.0]hex-3-ene derivatives based on the skeleton of five-membered pyrazole moiety have been synthesized and characterized by spectral techniques, as well as their photochromic properties were examined under UV light irradiation in various solutions. All these newly synthesized compounds showed good photochromic properties in the both solution and solid states. The UV-Visible spectral analysis of the corresponding pyrazolyl bicyclic aziridines established structure-photochromic behavior relationships.

Synthesis of new ferrocenyl 1,3-diazabicyclo[3.1.0]hex-3-ene derivatives

In this work, several new derivatives of ferrocenyl bicylic aziridine photochromic compounds have been prepared from the premade ketoaziridines and ferrocene carboxaldehyde in the presence of ammonium acetate in absolute ethanol via one-pot, three-component reaction. The structures of the newly synthesized compounds were established on the basis of IR, NMR and UV-Vis spectral studies. The newly synthesized compounds exhibit interesting photochromic behavior in the solid phase and solution state. The photochromic behavior of the prepared compounds has been investigated by UV-Visible spectral data.

Efficient aziridination of α,β-unsaturated ketones with O-(2,4-dinitrophenyl)-hydroxylamine

The aziridination of α,β-unsaturated ketones with O-(2,4-dinitrophenyl)-hydroxylamine and tertiary amine was developed. trans-Aziridines were obtained exclusively in good yields. The reaction is proposed to occur via an aminimide intermediate. Copyright T

NMR structural elucidation and photochromic behavior of new 1,3-diazabicyclo[3.1.0]hex-3-ene derivatives

Several 6-(4-nitrophenyl)-4-phenyl-1,3-diazabicyclo[3.1.0]hex-3-ene derivatives having various substituents on C2 were synthesized, and their 1H NMR spectra and photochromic behavior were examined.

Photochromic behavior of several new synthesized bis-1, 3-diazabicyclo[3.1.0]hex-3-enes

Photochromic compounds (1-6) are synthesized and characterized and the results of their spectra are presented. The structure-photochromic behavior relationship (SPBR) of the synthesized compounds has been analyzed. Copyright

Synthesis and photochromic properties of new heterocyclic derivatives of 1,3-diazabicyclo[3.1.0]hex-3-ene

The facile synthesis of several 1,3-diazabicyclo[3.1.0]hex-3-ene derivatives with varying substitutions such as 2-methyl-6-(4-nitrophenyl)-2,4- diphenyl-(1), 2-methyl-6-(4-nitrophenyl)-4-phenyl-2-(pyridin-3-yl)-(2), 2-(furan-2-yl)-6-(4-nitrophenyl)-4-phenyl-(3), 2-(furan-2-yl)-6-(3-nitrophenyl)- 4-phenyl-(4), 6-(3-nitrophenyl)-2,4-diphenyl-(5) and 6-(4-chlorophenyl)-4-(3- nitrophenyl)-2-phenyl-(6) that all behave as "intelligent materials" are reported.

An amine-promoted aziridination of chalcones

(Chemical Equation Presented) Without protection: α-Keto aziridines have been formed in a novel amine-promoted direct aziridination of chalcones using an aminimide generated in situ from a tertiary amine and O-mesitylenesulfonylhydroxylamine (MSH) in the

Photochromism of several synthesised 1,3-diazabicyclo[3,1,0]hex-3-ene derivatives

Several 1,3-diazabicyclo[3,1,0]hex-3-ene derivatives with varying substitutions such as 9H-fluorenyl, 4-(cyclohexylphenyl)-2-methyl, 4-cyclohexyl phenyl, 2-phenyl-2-methyl, and 2-cyclohexyl-2-phenyl that behave as "intelligent material" are reported.

Catalytic conversion of conjugated enones into optically active α-keto aziridines using chiral rare earth metal complexes

Optically active N-unsubstituted α-keto aziridines 2 were synthesized from conjugated enones 1 via the Sc[(R)-BNP]3-catalyzed enantioselective Michael addition of O-methylhydroxylamine followed by the La(O-i-Pr)3-catalyzed ring closu

Direct NH-aziridination of α,β-unsaturated ketones

1-Aryl-α,β-unsaturated ketones were directly aziridinated, N-unsubstituted, in a one-pot reaction with satisfactory yields by N,N′-diamino-1,4-diazoniabicyclo[2.2.2]octane dinitrate, a nitrogen-nitrogen ylide precursor, in the presence of sodium hydride.