76361-67-6

Upstream product

• 136054-86-9 2'-hydroxy-4'-methoxy-ω-cinnamylidene acetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 21947-71-7 cinnamic anhydride 
• 101396-11-6 1-(2-hydroxy-4-methoxyphenyl)butane-1,3-dione 
• 102-92-1 Cinnamoyl chloride 
• 14371-10-9 (E)-3-phenylpropenal 
• 104-55-2 3-phenyl-propenal 
• 538-56-7 cinnamic acid anhydride 
• 26213-82-1 7-methoxy-2-methyl-chromen-4-one 
• 100-52-7 benzaldehyde 
• 126525-74-4 1-(2-hydroxy-4-methoxyphenyl)-3-(2-phenylethenyl)propane-1,3-dione 

Relevant academic research and scientific papers

One-Pot Green Synthesis of 2-Hydroxybenzoyl(cinnamoyl)methanes and 2-Styrylchromones Using Dual-Frequency Ultrasonication

Abstract: One-pot green synthesis of (2-hydroxybenzoyl)(cinnamoyl)methanes has been performed by reacting 2-hydroxyacetophenones with cinnamoyl chlorides using activated Ba(OH)2, followed by Baker–Venkataraman rearrangement assisted by dual-fre

2-Styrylchromone derivatives as potent and selective monoamine oxidase B inhibitors

A series of eighteen 2-styrylchromone derivatives (see Chart 1) were synthesized and evaluated for their monoamine oxidase (MAO) A and B inhibitory activities. Many of the derivatives inhibited MAO-B comparable to pargyline (a positive control), and most of them inhibited MAO-B selectively. Of the eighteen derivatives, compound 9 having methoxy group at R1 and chlorine at R4 showed both the best MAO-B inhibitory activity (IC50 = 17 ± 2.4 nM) and the best MAO-B selectivity (IC50 for MAO-A/IC50 for MAO-B = 1500). The mode of inhibition of compound 9 against MAO-B was competitive and reversible. Quantitative structure–activity relationship (QSAR) analyses of the 2-styrylchromone derivatives were conducted using their pIC50 values with the use of Molecular Operating Environment (MOE) and Dragon, demonstrating that the descriptors of MAO-B inhibitory activity and MAO-B selectivity were 1734 and 121, respectively, that showed significant correlations (P 50 value indexes for MAO-B exhibited a determination coefficient (R2) of 0.873 as well as a Leave-One-Out cross-validated determination coefficient (Q2) of 0.675. These data suggested that the 2-styrylchromone structure might be a useful scaffold for the design and development of novel MAO-B inhibitors.

Microwave assisted synthesis of 1-(2-hydroxyphenyl)-5-phenyl pent-4-ene-1,3-diones and their conversion to 2-styryl chromones

A simple and efficient method has been developed for the rapid synthesis of 1-(2-hydroxyphenyl)-5-phenyl pent-4-ene-1,3-diones 3a-g in a single pot reaction under microwave irradiation. These β-diketones are further converted into 2-styryl chromones again

Oxidative cyclization of o-hydroxy-ω-cinnamylideneacetophenones to 2-styrylchromones with potassium iodate-dimethyl sulphoxide

o-Hydroxy-ω-cinnamylideneacetophenones (1) have been found to undergo oxidative cyclization to the corresponding 2-styrylchromones (2) in satisfactory yields by heating them with potassium iodate in dimethyl sulphoxide.

A modified synthesis of 2-styrylchromones

2-Hydroxy-ω-cinnamylideneacetophenones (3a-e) have been obtained by condensation of 2-hydroxyacetophenones (1) with cinnamaldehyde (2) in the presence of barium hydroxide.Oxidative cyclisation of the compounds 3a-e with iodine in dimethyl sulphoxide provi

A CONVENIENT SYNTHESIS OF 2-STYRYLCHROMONES BY MODIFIED BAKER-VENKATARAMAN TRANSFORMATION USING PHASE TRANSFER CATALYSIS.

Condensation of 2-hydroxyacetophenones 1 with cinnamic anhydrides 2 in the presence of tetra-n-butyl ammonium hydrogen sulfate in benzene-aqueous potassium carbonate biphase medium give 1-(2-hydroxyphenyl)-5-phenyl-4-pentene-1,3-diones 3 which on cyclodeh