76377-04-3

Basic information

• Product Name: 1,4,7,10,13,16-Hexaoxacyclooctadecane, 2-[(phenylmethoxy)methyl]-
• Synonyms: 2-Benzyloxymethyl-1,4,7,10,13,16-hexacyclooctadecan
• CAS NO: 76377-04-3
• Molecular Formula: C20H32O7
• Molecular Weight: 384.47
• Mol File: 76377-04-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,4,7,10,13,16-Hexaoxacyclooctadecane, 2-[(phenylmethoxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10,13,16-Hexaoxacyclooctadecane, 2-[(phenylmethoxy)methyl]-(76377-04-3)
• EPA Substance Registry System: 1,4,7,10,13,16-Hexaoxacyclooctadecane, 2-[(phenylmethoxy)methyl]-(76377-04-3)

Safety Data

• Hazardous Substances Data: 76377-04-3(Hazardous Substances Data)

Upstream product

• 13071-59-5 3-benzyloxypropan-1,2-diol 
• 5197-65-9 1,14-dichloro-3,6,9,12-tetraoxatetradecane 
• 41024-91-3 penta(ethylene glycol) bis(p-toluenesulfonate) 
• 15028-56-5 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 80525-59-3 4-[(benzyloxy)methyl]-3,6-dioxaoctane-1,8-dicarboxylic acid 
• 80525-60-6 4-Benzyloxymethyl-3,6-dioxa-1,8-octanediol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 114951-76-7 1-(benzyloxymethyl) triethylene glycol 
• 2930-05-4 Benzyloxymethyl-oxiran 

Downstream Products

• 83585-76-6 ((dodecyloxy)methyl)-18-crown-6 
• 70069-04-4 2-hydroxymethyl-18-crown-6 

Relevant articles and documents

Synthesis of Novel C-Pivot Lariat 18-Crown-6 Ethers and Their Efficient Purification

The syntheses of various lariat ethers including several not previously reported and their efficient purification are presented. The synthesis route brings together reactions from a variety of previous works leading to a robust and generalized approach to these C-pivot lariats. The main steps are condensation of functionalized diols with pentaethylene glycol ditosylate in the presence of potassium as a templating cation. Purification of the final products was achieved without chromatography by extracting from an aqueous potassium hydroxide solution.

A CONVENIENT SYNTHESIS OF CROWN AND AZACROWN ETHERS WITH PENDANT OXIRANE GROUP

Synthesis of 4,5-epoxy-2-oxa-1-pentylcrown (I) and N-(2,3-epoxy-1-propyl)azacrown ethers (II) from accessible materials is described.

Synthesis and Alkali-cation Complexing Properties of 12-Crown-4 Derivatives

Benzyloxymethyl-12-crown-4, a precursor of hydroxymethyl-12-crown-4, is prepared in an excellent yield by the reaction of 3-benzyloxy-1,2-propanediol with 1,8-dichloro-3,6-dioxaoctane in the heterogeneous t-BuOLi/t-BuOH/LiBr*2H2O reaction system.The hydrogenolysis in the presence of p-toluenesulfonic acid leads to a good yield of hydroxymethyl-12-crown-4.The sandwich-type 2:1 complexation with Na+ of 12-crown-4 and hydroxymethyl-12-crown-4 derivatives was discussed on the basis of the stability constants and the solvent extraction in the CH2Cl2-water system.