70069-04-4

Basic information

• Product Name: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL
• Synonyms: 2-HYDROXYMETHYL-18-CROWN-6;2-(HYDROXYMETHYL)-18-CROWN 6-ETHER;18-CROWN-6-METHANOL;1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL;1,4,7,10,16-hexaoxcyclooctadecane-2-methanol;1,4,7,10,13,16-Hexaoxacyclooctadecane-2-methanol, 18-Crown-6-methanol;1,4,7,10,13,16-Hexaoxacyclooctadecane-3-methanol;2-(Hydroxymethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane
• CAS NO: 70069-04-4
• Molecular Formula: C₁₃H₂₆O₇
• Molecular Weight: 294.34
• EINECS: 274-299-3
• Product Categories: Crown Ethers;Functional Materials;Macrocycles for Host-Guest Chemistry
• Mol File: 70069-04-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 150 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /Liquid
• Density: 1.174 g/mL at 25 °C(lit.)
• Vapor Pressure: 3.97E-10mmHg at 25°C
• Refractive Index: n20/D 1.479(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble in water (1000 g/L) (25°C).
• BRN: 4313301
• CAS DataBase Reference: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL(70069-04-4)
• EPA Substance Registry System: 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE-2-METHANOL(70069-04-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 70069-04-4(Hazardous Substances Data)

Usage

Uses

2-Hydroxymethyl-18-crown-6 is used for chemical research.

InChI:InChI=1/C13H26O7/c14-11-13-12-19-8-7-17-4-3-15-1-2-16-5-6-18-9-10-20-13/h13-14H,1-12H2

Upstream product

• 50-00-0 formaldehyd 
• 17455-13-9 18-crown-6 ether 
• 76377-06-5 18-crown-6-carboxaldehyde 
• 84812-04-4 <(Allyloxy)-methyl>-18-crown-6 
• 76377-04-3 2-Benzyloxymethyl-1,4,7,10,13,16-hexacyclooctadecan 
• 41024-91-3 penta(ethylene glycol) bis(p-toluenesulfonate) 
• 84812-09-9 1-((allyloxy)methyl)-3,6,9-oxa-undecane-1,11-diol 
• 4792-15-8 Pentaethylene glycol 
• 114951-76-7 1-(benzyloxymethyl) triethylene glycol 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 76377-05-4 (+/-)-2-Diethoxymethyl-1,4,7,10,13,16-hexaoxacyclooctadecan 

Downstream Products

• 94978-63-9 2-((4-nitrophenoxy)methyl)-18-crown-6 
• 1550166-78-3 ((1,4,7,10,13,16-hexaoxacyclooctadecan-2-yl)methoxy)-(tert-butyl)diphenylsilane 
• 1287753-20-1 C₂₀H₂₉IO₈ 
• 1143623-75-9 1,4,7,10,13,16-hexaoxacyclooctadecan-2-ylmethyl 4-[6-(acryloyloxy)hexyloxy]benzoate 
• 1143623-79-3 1,4,7,10,13,16-hexaoxacyclooctadecan-2-ylmethyl 4-{(E)-4-[(2-acryloyloxyethyl)(ethyl)amino]phenyldiazenyl}benzoate 
• 1031207-83-6 C₃₄H₅₈O₁₄ 

Relevant articles and documents

Facile Synthesis of Hydroxymethylcrown Ethers

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Synthesis of Novel C-Pivot Lariat 18-Crown-6 Ethers and Their Efficient Purification

The syntheses of various lariat ethers including several not previously reported and their efficient purification are presented. The synthesis route brings together reactions from a variety of previous works leading to a robust and generalized approach to these C-pivot lariats. The main steps are condensation of functionalized diols with pentaethylene glycol ditosylate in the presence of potassium as a templating cation. Purification of the final products was achieved without chromatography by extracting from an aqueous potassium hydroxide solution.

A CONVENIENT SYNTHESIS OF CROWN AND AZACROWN ETHERS WITH PENDANT OXIRANE GROUP

Synthesis of 4,5-epoxy-2-oxa-1-pentylcrown (I) and N-(2,3-epoxy-1-propyl)azacrown ethers (II) from accessible materials is described.