76379-01-6

Upstream product

• 6461-04-7 (R)-2-amino-5-methoxy-5-oxopentanoic acid 
• 34619-03-9 tert-butyldicarbonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 27025-22-5 D-glutamic acid-5-methyl ester; hydrochloride 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 6893-26-1 D-Glutamic acid 

Downstream Products

• 76379-02-7 t-butoxycarbonyl-D-glutamic acid γ-methyl ester dicyclohexylamine salt 
• 1389332-14-2 C₂HF₃O₂*C₂₇H₃₇N₉O₈ 
• 1389332-63-1 C₄₁H₅₇N₉O₁₁S 
• 1389332-56-2 C₄₁H₅₉N₉O₁₂S 
• 1389332-49-3 C₅₆H₇₁N₉O₁₄S 
• 1389332-40-4 C₄₅H₆₀N₈O₁₁S 
• 1389331-93-4 C₂₀H₂₇N₃O₆ 
• 1389332-20-0 C₂₁H₂₉N₃O₆ 
• 1389332-19-7 C₁₆H₁₉N₅O₄ 
• 1389331-99-0 C₁₆H₂₀N₂O₅ 
• 1316756-69-0 ethyl {(2S,5R,6S)-5-[bis(cyclopentylmethyl)amino]-6-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate 
• 1316756-72-5 ethyl {(2R,5R,6S)-5-[bis(cyclopentylmethyl)amino]-6-[4-(trifluoromethyl)phenyl]tetrahydro-2H-pyran-2-yl}acetate 
• 1316756-68-9 ethyl (2E,6R,7S)-6-[bis(cyclopentylmethyl)amino]-7-hydroxy-7-[4-(trifluoromethyl)phenyl]hept-2-enoate 
• 1316756-98-5 ethyl (2E,6R)-6-(dibenzylamino)-7-hydroxyhept-2-enoate 

Relevant academic research and scientific papers

Inhibition of glyoxalase I: The first low-nanomolar tight-binding inhibitors

A series of rational modifications to the structure of known S-(N-aryl-N-hydroxycarbamoyl)glutathione-based glyoxalase I inhibitors culminated in the discovery of the first single-digit nanomolar inhibitor. This study makes available key information about possible means to address the issues of metabolic instability, low potency, and synthetic complexicity that have plagued the area of glyoxalase I inhibition. Knowledge garnered from this study has implications in the design of inhibitors with higher conformational definition and lower peptidic character.

Synthesis of enantiomerically pure β- and γ-amino acids from aspartic and glutamic acid derivatives

An efficient synthesis of enantiomerically pure β- and γ-amino acids starting from commercially available aspartic and glutamic acid derivatives is described. The acid function, α to the amino group, is first transformed to a good leaving group and the pr

Glucosamine peptide derivatives, their production and use

Novel glucosamine-peptide derivatives of the formula: STR1 wherein m is 0 or 1; n is 0 or an integer of 1 to 9; R is lower alkyl which may be substituted with hydroxyl, or aryl; R1 is hydrogen or acyl having an acyclic hydrocarbon group, the terminal of which may be substituted with a cyclic hydrocarbon group directly, via a carbonyl group or via an oxygen atom; provided that when R1 is hydrogen m is 1; R2 is hydrogen or lower alkyl which may form a ring by connecting its terminal with the α-nitrogen atom when n is 0, or hydrogen when n is an integer of 1 to 9; R3 is hydrogen or lower alkyl; R4 and R5 are each hydrogen or lower alkyl which may be substituted with hydroxyl or benzyloxyl; R6 is hydrogen or lower alkyl; R7 is alkyl which may be substituted with lower alkoxyl or aralkyl; R8 and R9 are each hydrogen, lower alkyl or aralkyl; and (D) and (L) each indicate configurations if their respective carbon atoms are asymmetric; or an acid addition salt thereof, have immunostimulatory activity.