76429-66-8

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DibroMo-1-(2-broMoethoxy)benzene is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DibroMo-1-(2-broMoethoxy)benzene is utilized as a starting material for the production of agrochemicals, such as pesticides and herbicides, due to its chemical properties that can be tailored for specific agricultural needs.
Used in Dye and Pigment Industry:
2,4-DibroMo-1-(2-broMoethoxy)benzene is employed as a component in the creation of dyes and pigments, taking advantage of its chemical structure to produce a wide range of colors for various applications, including textiles, plastics, and printing inks.
Used in Specialty Chemicals Production:
2,4-DibroMo-1-(2-broMoethoxy)benzene is also used as a starting material for the synthesis of specialty chemicals, such as flame retardants and plasticizers, where its unique properties can enhance the performance of these materials.
Used in Medicinal Chemistry:
2,4-DibroMo-1-(2-broMoethoxy)benzene serves as a precursor for the synthesis of biologically active molecules in medicinal chemistry, playing a crucial role in the development of new therapeutic agents with improved efficacy and selectivity.

Upstream product

• 615-58-7 2,4-dibromophenol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 66826-78-6 5-bromo-2,3-dihydrobenzo[b]furan 
• 639514-19-5 C₂₃H₁₉F₃N₂O₆S₂ 
• 76429-73-7 2,3-dihydrobenzofuran-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, antimicrobial evaluation, and in silico studies of quinoline—1H-1,2,3-triazole molecular hybrids

Abstract: Antimicrobial resistance has become a significant threat to global public health, thus precipitating an exigent need for new drugs with improved therapeutic efficacy. In this regard, molecular hybridization is deemed as a viable strategy to afford multi-target-based drug candidates. Herein, we report a library of quinoline—1H-1,2,3-triazole molecular hybrids synthesized via copper(I)-catalyzed azide-alkyne [3 + 2] dipolar cycloaddition reaction (CuAAC). Antimicrobial evaluation identified compound 16 as the most active hybrid in the library with a broad-spectrum antibacterial activity at an MIC80 value of 75.39?μM against methicillin-resistant S. aureus, E. coli, A. baumannii, and multidrug-resistant K. pneumoniae. The compound also showed interesting antifungal profile against C. albicans and C. neoformans at an MIC80 value of 37.69 and 2.36?μM, respectively, superior to fluconazole. In vitro toxicity profiling revealed non-hemolytic activity against human red blood cells (hRBC) but partial cytotoxicity to human embryonic kidney cells (HEK293). Additionally, in silico studies predicted excellent drug-like properties and the importance of triazole ring in stabilizing the complexation with target proteins. Overall, these results present compound 16 as a promising scaffold on which other molecules can be modeled to deliver new antimicrobial agents with improved potency. Graphic abstract: [Figure not available: see fulltext.].

An Efficient K2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane Derivatives and Evaluation of Larval Mortality against Aedes aegypti

The influences of reaction parameters on the etherification of phenols to obtain 1-bromo-2-aryloxyethane derivatives were evaluated. The compounds were prepared by direct etherification of phenols with 1,2-dibromoethane using anhydrous K2CO3 and acetonitrile as solvent reaction, at 80°C, in a reaction time of 6 h. Under these conditions, excellent yields (71%-94%) were obtained, with low yields of secondary products. The anhydrous K2CO3 was recycled by simple filtration, dried in vacuum, and reused. The compounds were characterized by conventional spectral data (MS and NMR). Larvicidal activity results showed a 100% larval mortality after 24-hour exposure to the compound 1-(2-bromoethoxy)-2-phenylbenzene.

Bromination of N-phenyloxypropyl-N′-ethyl-4,4′-bipyridium in cucurbit[8]uril molecular reactor

CB[n] (n?=?6–8) is a family of synthetic macrocyclic host molecules composed of n glycoluril units, which can be employed as molecular reactor. N-Phenyloxypropyl-N′-ethyl-4,4′-bipyridium (1) was designed to form a host–guest inclusion complex with CB[n] (n?=?6–8), subsequently, the bromination reaction of 1 and its corresponding inclusion complexes was investigated in this work. In the case of 1/CB[8], the folded including mode is quite helpful to acquire 1-bormination product completely through intramolecular charge transfer (ICT), and CB[8] can provide a safe bromination environment for 1.

CANNABINOID RECEPTOR AGONISTS

A compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1, R2, R3, R4, R5, R6, L1, L2, M, n, p, X, Y and Z are as described in the specification; pharmaceutical compositions thereof, methods of making said pharmaceutical compositions; and methods of use thereof.

Oxygen Heterocycles by the Parham Cyclialkylation

The addition of butyllithium at -100 deg C to ω-bromoalkyl ethers of o-bromophenol (and its congeners) led to preferential exchange of the aryl bromine at position 2.The resulting organolithium reagents, under suitable conditions, cyclized to afford 2,3-dihydrobenzofurans (6), 3,4-dihydro-2H-1-benzopyrans (13), or 2,3,4,5-tetrahydro-1-benzoxepins (16) in good yields, but less satisfactory results were obtained with the intermediate expected to produce 8-methyl-3,4,5,6-tetrahydro-2H-1-benzoxocin (19). ω-Bromoethyl and ω-bromopropyl ethers of suitable dibromophenols were treated successively with 2 equiv of butyllithium and an electrophile to yield derivatives of 6 and 13.