76461-89-7

Upstream product

• 1635-31-0 aminocoumarine 
• 140-10-3 (E)-3-phenylacrylic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 779-30-6 3-acetamidocoumarin 
• 115127-03-2 N-cinnamoylamino glycine 
• 90-02-8 salicylaldehyde 
• 2549-08-8 3-benzamidocoumarin 
• 16534-24-0 (E)-cinnamoylglycine 

Relevant academic research and scientific papers

Novel synthesis and cytotoxic activity of some chromeno[3,4-b]pyrrol-4(3H)- ones

1-Methylchromeno[3,4-b]pyrrol-4(3H)-one and 1-phenylchromeno[3,4-b]pyrrol- 4(3H)-one derivatives have been synthesized by cyclization of amides obtained by condensing α-halo ketones with 3-amino-chromenones, which show cytotoxic activity against lung, colon, and breast cancer cell lines.

Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines

A series of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines were synthesized and evaluated for their antihyperglycemic activity. Compounds 3g and 6d exhibited lowering of postprandial plasma glucose by 30.7%, 23.3% in SLM and 25.6%, 25.4% in STZ models respectively which is significant compared to metformin and glybenclamide. Other compounds exhibited moderate to good activity ranging from 19.5% to 32.8% in SLM and 3.26% to 25.4% in STZ models.

Reactions of 2-Substituted 5-Oxazolones with Imines Carrying a Vicinal Hydroxyl Group & Salicylaldehyde

5-Oxazolones, generated by cyclising N-acylglycines with ethyl chloroformate, react with imines carrying a vicinal hydroxyl group and also with salicylaldehyde.Unsaturated 5-oxazolone or 3-N-acylaminocoumarin is obtained depending on the type of reactants.