764680-75-3

Upstream product

• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 106-93-4 ethylene dibromide 
• 871813-88-6 4-(2-bromoethoxy)-5-methoxy-2-nitrobenzoic acid 
• 871813-86-4 methyl 4-(2-bromoethoxy)-3-methoxybenzoate 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 

Downstream Products

• 871949-92-7 (2S)-N-{4-[2-[4-[2-(1,3-dioxo-benz[de]isoquinolin-2-yl)ethyl]piperazin-1-yl]-ethyl]oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethylthioacetal 
• 871813-94-4 1,1'-{[(bisethane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] 
• 764680-77-5 1,1'-{[(bisethane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy2-nitro-benzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] 

Relevant academic research and scientific papers

PYRROLO[2,1-C][1,4]BENZODIAZEPINE-NAPTHALIMIDE CONJUGATES LINKED THROUGH PIPERAZINE MOIETY AND PROCESS FOR PREPARATION THEREOF

The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety as potential antitumour agents. The present invention also relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]

DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer

New pyrrolobenzodiazepine (PBD) dimers have been developed that are composed of two DC-81 subunits tethered to their C8 positions through piperazine moiety side-armed with alkaneoxy linkers (composed of 2-5 carbons). DNA thermal denaturation studies show

Pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide conjugates linked through piperazine moiety and process for preparation thereof

The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepine-napthalimide hybrids linked through piperazine moiety as potential antitumour agents. The present invention also relates to a process for the preparation of novel pyrrolo[2,1-c][1,4]

Pyrrolo[2,1-c][1,4] benzodiazepines compounds and process thereof

The present invention provides Analogues of 1,1′-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n=2 to 10; a pharmaceutical composition comprising the above

PYRROLO[(2,1-C)(1,4) BENZODIAZEPINES DIMERS AS ANTITUMOUR AGENTS AND PROCESS THEREOF

The present invention provides Analogues of 1, 1'-{[(bisalkane-1,N-diyl)piperazine]dioxy}bis(11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one] of formula (VI) where n = 2 to 10; a pharmaceutical composition comprising the abo