871813-86-4

Upstream product

• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 106-93-4 ethylene dibromide 

Downstream Products

• 1081314-01-3 C₁₅H₂₁NO₅ 
• 764680-77-5 1,1'-{[(bisethane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy2-nitro-benzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] 
• 871813-94-4 1,1'-{[(bisethane-1,N-diyl)piperazine]dioxy}bis[(11aS)-7-methoxy-2-aminobenzoylpyrrolidin-2-carboxaldehyde diethylthioacetal] 
• 764680-75-3 (2S)-N-[4-(2-bromoethoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 871813-88-6 4-(2-bromoethoxy)-5-methoxy-2-nitrobenzoic acid 
• 871813-87-5 methyl 4-(2-bromoethoxy)-5-methoxy-2-nitrobenzoate 

Relevant academic research and scientific papers

ANTIVIRAL HETEROCYCLIC COMPOUNDS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Molecularly imprinted artificial esterases with highly specific active sites and precisely installed catalytic groups

A difficult challenge in synthetic enzymes is the creation of substrate-selective active sites with accurately positioned catalytic groups. Covalent molecular imprinting in cross-linked micelles afforded such active sites in protein-sized, water-soluble nanoparticle catalysts. Our method allowed a systematic tuning of the distance of the catalytic group to the bound substrate. The catalysts displayed enzyme-like kinetics and easily distinguished substrates with subtle structural differences.

DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer

New pyrrolobenzodiazepine (PBD) dimers have been developed that are composed of two DC-81 subunits tethered to their C8 positions through piperazine moiety side-armed with alkaneoxy linkers (composed of 2-5 carbons). DNA thermal denaturation studies show