76470-86-5Relevant academic research and scientific papers
Carbostyril derivatives
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, (2008/06/13)
Novel carbostyril derivative and its salt represented by the general formula (1), STR1 wherein R1 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a phenyl-lower alkyl group; R2 is a hydrogen atom, a lower alkyl group or a group of the formula STR2 wherein A is a lower alkylene group; R3 is a lower alkyl group, a hydroxy lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or a benzoyloxy-lower alkyl group; and R4 is a C3-10 -cycloalkyl group which may have at least one hydroxyl group as the substituent(s) in the cycloalkyl ring, a C3-10 -cycloalkyl-lower alkyl group, a phenyl group, a phenyl-lower alkyl group which may have at least one lower alkoxy group as the substituent(s) in the phenyl ring, a lower alkyl group which may have at least one hydroxyl group as the substituent(s), a heterocyclic ring residue or a lower alkyl group having one heterocyclic ring residue as the substituent; further, R3, R4 and the adjacent nitrogen atom, as well as with or without another nitrogen atom, may form a group of the formula STR3 (wherein R5 is a phenyl group, a C3-10 -cycloalkyl group or a phenyl-lower alkyl group; and B is a methine group or a nitrogen atom); the carbon-carbon bond between the 3- and 4-positions in the carbostyril skeleton is a single or double bond; the substituted position of the group of the formula STR4 is any one of 5-, 6-, 7- or 8-position in the carbostyril skeleton; when the group of the formula STR5 is substituted at 5-, 6-, 7- or 8-position in the carbostyril skeleton, then R2 is a hydrogen atom or a lower alkyl group; alternatively, when R2 is a group of the formula STR6 then 5-, 6-, 7- and 8-positions in the carbostyril skeleton are hydrogen atoms and are not substituted with groups of the formula STR7 and when R3 is a lower alkyl group, then R4 should be neither of a C3-10 -cycloalkyl group, a C3-10 -cycloalkyl-lower alkyl group nor a lower alkyl group, having effects for preventing and treating thrombosis and embolism.
Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. III. N-cyclohexyl-N-(2-hydroxyethyl)-4-(1,2-dihydro-2-oxo-6-quinolyloxy) butyramide and related compounds
Nishi,Tabusa,Tanaka,Ueda,Shimizu,Kanbe,Kimura,Nakagawa
, p. 852 - 860 (2007/10/02)
A series of N,N-disubstituted-ω-(1,2-dihydro-2-oxoquinolyloxy)alkanecarboxamides was synthesized and tested for inhibitory activity towards collagen- and ADP-induced aggregation of rabbit blood platelet in vitro. These compounds were prepared by the react
