76480-50-7Relevant academic research and scientific papers
New Pyrimidino-Crown Ether Ligands
Redd, J.Ty,Bradshaw, Jerald S.,Huszthy, Peter,Izatt, Reed M.
, p. 1047 - 1052 (2007/10/02)
Eight new macrocyclic ligands containing the pyrimidine subcyclic unit (3-10 Figure 1) have been prepared.Two of these new crown ethers are chiral.Pyrimidino-crowns 3-8 were prepared by treating the ditosylate derivative of the appropriate oligoethylene glycol with 4-methoxy-5-methyl-2,6-pyrimidinedimethanol in basic conditions.The yields were in the 30-50percent range giving the crowns as viscous oils.Chiral dimethyl-substituted pyrimidino-crown 9 was prepared from 4-methoxy-5-methyl-2,6-pyrimidinedimethyl ditosylate and chiral dimethyl-substituted tetraethylene glycol.Treatment of dimethyl 4-methoxy-5-methyl-2,6-pyrimidinedicarboxylate with the diamine derivative of chiral dibenzyl-substituted tetraethylene glycol gave the chiral dibenzyl-substituted pyrimidino-crown diamide 10.Starting 4-methoxy-5-methyl-2,6-pyrimidinedimethanol was prepared by a six step process from acetamidine hydrochloride and diethyl oxalpropionate.
Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin
Hagmann, William K.,Basha, Fatima Z.,Hashimoto, Mitsunori,Frye, Bruce R.,Kojo, Shosuke,Hecht, Sidney M.
, p. 1413 - 1423 (2007/10/02)
Synthetic approaches to 2-substituted pyrimidines have been studied in an effort to facilitate the preparation of the pyrimidine moiety of bleomycin (2).Ethyl 2,5-dimethyl-4-oxopyrimidine-6-carboxylate (4) has been utilized as starting material; its conve
