76497-31-9Relevant academic research and scientific papers
Synthesis of dirhodium(II) tetrakis[methyl 1-(3-phenylpropanoyl)-2- oxaimidazolidine-4(S)-carboxylate], Rh2(4S-MPPIM)4
Doyle, Michael P.,Colyer, John T.
, p. 3601 - 3604 (2003)
The large-scale synthesis with greatly improved yields of methyl 1-(3-phenylpropanoyl)-2-oxaimidazolidine-4(S)-carboxylate and the chiral dirhodium(II) carboxamidate derived from it, Rh2(4S-MPPIM) 4, is described. The key step in the
HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
-
Page/Page column 177, (2021/02/19)
The application relates to heterocyclic amide derivatives and their use in the treatment and prophylaxis of cancer, and to compositions containing said derivatives and processes for their preparation. (Formula (I))
Pyridine ketone compound and its composition and use thereof (by machine translation)
-
Paragraph 0261; 0263; 0264, (2017/08/25)
The invention relates to the field of blood coagulation. In particular, the invention relates to a pyridone compound, or a stereoisomer thereof, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug and pharmaceutical composition containing the compound. The invention also relates to such compounds and pharmaceutical composition preparation method, and they in preparing for the prevention, treatment or alleviation of patient Xa factor relative thromboembolic disease in use. (by machine translation)
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
-
Page/Page column, (2015/02/19)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
THERAPEUTICALLY ACTIVE COMPOUNDS AND USE THEREOF
-
Page/Page column 162, (2015/02/19)
Provided are therapeutically active compounds and the use in manufacture of medicaments for treating a cancer characterized by the presence of a mutant allele of IDH1.
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
-
Page/Page column 163, (2015/02/19)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
-
Page/Page column, (2013/07/31)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
-
Page/Page column 163, (2013/07/31)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor
Abberley, Lee,Bebius, Aude,Beswick, Paul J.,Billinton, Andy,Collis, Katharine L.,Dean, David K.,Fonfria, Elena,Gleave, Robert J.,Medhurst, Stephen J.,Michel, Anton D.,Moses, Andrew P.,Patel, Sadhana,Roman, Shilina A.,Scoccitti, Tiziana,Smith, Beverley,Steadman, Jon G.A.,Walter, Daryl S.
scheme or table, p. 6370 - 6374 (2010/12/18)
A backup molecule to compound 2 was sought by targeting the most likely metabolically vulnerable site in this molecule. Compound 18 was subsequently identified as a potent P2X7 antagonist with very low in vivo clearance and high oral bioavailability in all species examined. Some evidence to support the role of P2X7 in the etiology of pain is also presented.
First attempts at differential diastereoselection in catalytic reactions of N-chirally substituted dirhodium(II) tetrakis[methyl 2-oxoimidazolidine-4(S)-carboxylates] with diazoacetates
Doyle,Timmons,Arndt,Duursma,Colyer,Bruenner
, p. 2156 - 2161 (2007/10/03)
Chiral attachments on 2-oxoimidazolidine-4(S)-carboxylate ligands for dirhodium(II) can provide differential diastereoselection in catalytic reactions of diazo compounds. The synthesis of these heterocyclic ligands from the readily available amino acid as
