76524-98-6Relevant academic research and scientific papers
Palladium-Catalyzed Regioselective C-H Bond Arylations of Benzoxazoles and Benzothiazoles at the C7 Position
Abdellaoui, Fatma,Youssef, Chiraz,Ben Ammar, Hamed,Roisnel, Thierry,Soulé, Jean-Fran?ois,Doucet, Henri
, p. 4248 - 4252 (2016)
We report herein, a very simple catalytic system for the direct arylation of benzoxazole and benzothiazole derivatives at C7 position, namely, phosphine-free PdCl2 associated with PivOK in NMP at 150 °C. (Thio)phenoxy chelation-assisted Pd-catalyzed C-H bond cleavage, from an opened intermediate, was proposed to explain this unique regioselectivity. This reaction allows the synthesis of 2-amino-6-arylphenols through the ring opening of the benzoxazole.
