76527-74-7

Upstream product

• 97-96-1 2-Ethylbutyraldehyde 
• 76527-75-8 <(methylphenylamino)methyl>diphenylphosphine oxide 

Downstream Products

• 79409-03-3 3-Ethyl-1-(methyl-phenyl-amino)-pentan-2-one 
• 76527-80-5 (Z)-3-ethyl-1-(N-methylanilino)-1-pentene 
• 76527-79-2 (E)-3-ethyl-1-(N-methylanilino)-1-pentene 

Relevant academic research and scientific papers

NOVEL APPLICATIONS OF α-AMINOSUBSTITUTED DIPHENYLPHOSPHINE OXIDES. THE CONVERSION OF ALDEHYDES INTO α-AMINOMETHYLKETONES.

Aromatic and aliphatic aldehydes (R3CHO) can be converted into α-aminomethylketones (R3COCH2NR1R2) via reaction with (α-aminomethyl)diphenylphosphine oxides.

Enamine synthesis using the Horner-Wittig reaction. Part 1. (Aminomethyl)diphenylphosphine oxides, new formyl anion equivalents

Using the Horner-Wittig reagent (morpholinomethyl)diphenylphosphine oxide (7), aromatic, aliphatic and α,β-unsaturated aldehydes are converted into morpholino enamines of their homologous aldehydes.With diphenylphosphine oxide (12), the same aldehydes, together with the ketones (cyclic as well as acyclic, both saturated and α,β-unsaturated), are converted into enamines of their homologous aldehydes.Both types of enamines are converted into the corresponding aldehydes by mild, acid-catalyzed hydrolysis, showing the utility of 7 and 12, as formyl anion equivalents.Preparation of each geometrical isomer of the N-methylanilino enamines is possible since the intermediate diastereoisomeric adducts 13 can be separated.