765276-64-0Relevant academic research and scientific papers
Synthesis of novel coumarin derivatives and in vitro biological evaluation as potential ptp 1b inhibitors
Sun, Cheng,Peng, Chune,Wang, Jian,Wang, Quan,Liu, Wei,Zhou, Honggang,Yang, Cheng
, p. 1711 - 1726 (2013/09/12)
The aim of protein tyrosine phosphatase 1B (PTP 1B) inhibitors is to develop effective drug for diabetes and obesity. Coumarin becomes as a good skeleton, and is often applied in drug design and synthesis. In this paper, we have synthesized a series of novel coumarin derivatives to be as potential PTP 1B inhibitors. The inhibition rate of compound 9 was more than 80%, and the IC50 value was 49.2 μM, which would be considered for further study.
Microwave assisted one pot synthesis of 7-substituted 2-(2-oxo-2H-chromen-3-yl)acetic acids as precursors of new anti-tumour compounds
Kovacova, Silvia,Kovacikova, Lucia,Lacova, Margita,Bohac, Andrej,Salisova, Marta
, p. 806 - 811 (2011/11/06)
Perkin condensation with subsequent intramolecular lactonisation as one pot syntheses of 2-(2-oxo-2H-chromen-3-yl)acetic acids VIIa-Xa has been studied. The required acids VIIa-Xa were prepared as precursors of recently discovered compounds possessing antineoplastic activities. Syntheses of VIIa-Xa were carried out using para substituted 2-hydroxybenzaldehydes II-VI, succinic acid anhydride, sodium succinate under thermal or microwave conditions. Significant shortening of the reaction time under microwave irradiation was observed (18-50 min instead of 1.5-5 h of heating). Microwave assisted reactions proceeded more smoothly to give higher yield of the required products VIIa-Xa (31-61 %) compared to those under classical thermal conditions e.g. 21.8 % for IXa (Hurenkamp et al., 2007). Seven reaction by-products were isolated and determined as 2H,2′H-3,3′-bichromene-2,2′-diones VIIb-Xb and (E)-3-(2-hydroxystyryl)-2H-chromen-2-ones VIIc-IXc.
Intramolecular energy transfer in a tetra-coumarin perylene system: Influence of solvent and bridging unit on electronic properties
Hurenkamp, Johannes H.,Browne, Wesley R.,Augulis, Ramnas,Puglys, Audrius,Van Loosdrecht, Paul H. M.,Van Esch, Jan H.,Feringa, Ben L.
, p. 3354 - 3362 (2008/10/09)
The synthesis and characterisation of a novel coumarin donor-perylene bisimide acceptor light-harvesting system is reported, in which an energy-transfer efficiency of >99% is achieved. Comparison of the excited-state properties of the donor-acceptor syste
