150-90-3

Basic information

• Product Name: Disodium succinate
• Synonyms: di-Sodiumsuccinatehexahyrate;dlsodiumsuccinate;Jantaran sodny;jantaransodny;Soduxin;Sodium succinate dibasic anhydrous;DISODIUM SUCCINATE 98+%;Succinic Acid Disodium Salt Anhydrous
• CAS NO: 150-90-3
• Molecular Formula: C₄H₄O₄*2Na
• Molecular Weight: 162.05
• EINECS: 205-778-7
• Mol File: 150-90-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 236.1 °C at 760 mmHg
• Flash Point: 110.9 °C
• Appearance: White/Crystalline Powder
• Density: 1.46 g/cm3
• Vapor Pressure: 0.0165mmHg at 25°C
• Storage Temp.: Store below +30°C.
• Solubility: 350g/l
• Water Solubility: 300 g/L (25 ºC)
• Merck: 13,8754
• BRN: 3917246
• CAS DataBase Reference: Disodium succinate(CAS DataBase Reference)
• NIST Chemistry Reference: Disodium succinate(150-90-3)
• EPA Substance Registry System: Disodium succinate(150-90-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25
• WGK Germany: 1
• RTECS: WM7751000
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 150-90-3(Hazardous Substances Data)

Usage

Description

Disodium succinate, also known as succinic acid disodium salt, is a sodium salt derived from succinic acid. It is a white crystalline powder that is used in various industries due to its unique properties. Disodium succinate is known for its role as an acidity regulator and flavor enhancer, particularly in the food industry. Additionally, it is used in the preparation of buffer solutions for the quantitative analysis of auxins and in the study of the effect of liquid phase on the basic properties of α-tricalcium phosphate (α-TCP) based cement, BIOPEX. It is also utilized in the synthesis of cadmium sulfide (CdS) nanoparticles using thiourea as a source for sulfide.

Uses

Used in Food Industry:
Disodium succinate is used as an acidity regulator and flavor enhancer for improving the taste and quality of various food products.
Used in Pharmaceutical Industry:
Disodium succinate is used as an ingredient in topical preparations for the treatment of cataract, as defined by ChEBI.
Used in Chemical Analysis:
Disodium succinate is used to prepare buffer solutions for the quantitative analysis of auxins, which are important plant hormones.
Used in Cement Industry:
Disodium succinate is used to study the effect of the liquid phase on the basic properties of α-tricalcium phosphate (α-TCP) based cement, BIOPEX, which can help in understanding and improving the properties of cement materials.
Used in Nanotechnology:
In the synthesis of cadmium sulfide (CdS) nanoparticles, disodium succinate is used with thiourea as a source for sulfide, contributing to the development of advanced materials and technologies.

Flammability and Explosibility

Notclassified

Purification Methods

Crystallise it twice from water (1.2mL/g) and dry it at 125o. It has been freed from other metal ions by passage of a 0.1M solution through a column of Dowex resin A-1 (Na form). It is hygroscopic. [Beilstein 2 H 606, 2 IV 1908.]

InChI:InChI=1/C4H6O4.2Na/c5-3(6)1-2-4(7)8;;/h1-2H2,(H,5,6)(H,7,8);;/q;2*+1/p-2

Synthetic route

sodium acetate (127-09-3) → sodium succinate (150-90-3) + sodium acetate radical

Conditions	Yield
In water-d2 Irradiation;

sodium maleate (3105-55-3, 5873-57-4, 7704-73-6, 17013-01-3, 18016-19-8, 30915-61-8, 44670-32-8, 54060-75-2, 72383-56-3, 371-47-1) → sodium succinate (150-90-3) + fumaric acid disodium salt (17013-01-3)

Conditions	Yield
With hydrogen; nickel at 30℃; under 735.06 Torr; for 0.5h; Product distribution;

succinic acid monomethyl ester sodium salt (50888-28-3) → sodium succinate (150-90-3)

Conditions	Yield
With sodium hydroxide In methanol; water at 20℃; Rate constant; Thermodynamic data; ΔH(excit.), ΔS(excit.); various solvents;
With sodium hydroxide at 25℃; Kinetics; Further Variations:; Temperatures; Solvents; Hydrolysis;

succinic acid monopropyl ester sodium salt (69361-29-1) → sodium succinate (150-90-3)

Conditions	Yield
With sodium hydroxide In water; acetone at 30℃; Rate constant; various solvents;

sodium glycolate (25289-18-3, 105938-46-3, 2836-32-0) + alkali + zinc → sodium succinate (150-90-3)

magnesium succinate (556-32-1, 33460-47-8) → sodium succinate (150-90-3)

Conditions	Yield
With sodium hydroxide In water for 1h; pH=12.4;
With sodium hydroxide In water for 1h; pH=12.4; Product distribution / selectivity;

calcium succinate (140-99-8, 25454-25-5, 27695-01-8, 27695-02-9, 27695-03-0) → sodium succinate (150-90-3)

Conditions	Yield
With sodium carbonate In water for 1h; pH=10.5;
With sodium carbonate In water for 1h; pH=10.5; Product distribution / selectivity;

α-ketoglutaric acid disodium salt (305-72-6) → sodium succinate (150-90-3)

Conditions	Yield
With hydrogenchloride; iron(II) ammonium sulfate; pseudomonas sp.AK1 γ-butyrobetaine hydroxylase; potassium chloride; γ-butyrobetaine hydrochloride In water-d2 pH=7.5; Kinetics; Reagent/catalyst; Enzymatic reaction;

succinic acid (110-15-6) + sodium carbonate (497-19-8) → sodium succinate (150-90-3)

Conditions	Yield
In water

succinic acid anhydride (108-30-5) → sodium succinate (150-90-3)

Conditions	Yield
With water; sodium hydroxide for 0.00277778h; pH=12.8;	>= 95 %Spectr.

butanedioic acid, monoethyl ester (1070-34-4) → sodium succinate (150-90-3)

Conditions	Yield
With water; sodium hydroxide for 0.00555556h; pH=13;	>= 95 %Spectr.

sodium maleate (3105-55-3, 5873-57-4, 7704-73-6, 17013-01-3, 18016-19-8, 30915-61-8, 44670-32-8, 54060-75-2, 72383-56-3, 371-47-1) → sodium succinate (150-90-3)

Conditions	Yield
With hydrogen; sodium hydroxide In methanol; water at 29.84℃; Kinetics; Catalytic behavior; Solvent;

Tetrahydrofurfuryl alcohol (97-99-4) + sodium succinate (150-90-3) → malic acid (617-48-1) + (tetrahydrofuran-2-ylmethoxy)butanedioic acid

Conditions	Yield
With lanthanum(III) chloride at 116℃; for 19h; Product distribution; also with other alcohols; variation of reaction time, temperature and proportion of reagents;	A 3% B 95%

[2,2]bipyridinyl (366-18-7) + copper(II) perchlorate hexahydrate + sodium succinate (150-90-3) → ([Cu2(succinato)2(2,2'-bipyridine)4(H2O)2](ClO4)4(H2O))(n)

Conditions	Yield
In methanol; water a MeOH soln. of 2,2'-bipyridine added dropwise to a MeOH soln. of Cu salt with stirring for 15 min, an aq. soln. of disodium succinate added slowly, refluxed for 2 h; cooled, filtered, kept in a CaCl2-desiccator for days; elem. anal.;	90%

tributyltin chloride (1461-22-9) + sodium succinate (150-90-3) → (n-Bu)3SnO2CCH2CH2CO2Sn(Bu-n)3

Conditions	Yield
In ethanol under N2 atm. disodium dicarboxylate was added to EtOH soln. (n-Bu)3SnCland stirred for 15 h at 40°C; soln. was filtered and evapd., residue was recrystd. from EtOH; elem. anal.;	85.5%

1,10-Phenanthroline (66-71-7) + copper(II) nitrate trihydrate + sodium succinate (150-90-3) → [Cu2(μ-OH2)2(succinato)(1,10-phenanthroline)2(NO3)2](n)

Conditions	Yield
In methanol; water a MeOH soln. of 1,10-phenanthroline added dropwise to a MeOH soln. of Cusalt with stirring for 15 min, an aq. soln. of disodium succinate added slowly, refluxed for 2 h; cooled, filtered, kept in a CaCl2-desiccator for days; elem. anal.;	85%

praseodymium(III) chloride hexahydrate + sodium succinate (150-90-3) → [Pr2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Pr salt with stirring, heated at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	82%

methanol (67-56-1) + N,N'-bis[2-carboxybenzomethyl]-N,N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol + water (7732-18-5) + sodium succinate (150-90-3) + sodium hydroxide (1310-73-2) + zinc(II) chloride (7646-85-7) → 4C31H29N4O5(3-)*2C4H4O4(2-)*10H2O*Na(1+)*2H3O(1+)*2Li(1+)*8Zn(2+)*23H2O*6CH4O*2Cl(1-)*3Br(1-)

Conditions	Yield
Stage #1: methanol; N,N'-bis[2-carboxybenzomethyl]-N,N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol; sodium hydroxide; zinc(II) chloride for 1h; Reflux; Stage #2: water; sodium succinate for 1h; Reflux;	82%

sodium succinate (150-90-3) + 1-chloromethylbenzindol-2(1H)-one (CMBI) (114044-23-4) → BIM hydrogen succinate (114044-30-3) + Succinic acid bis-(2-oxo-2H-benzo[cd]indol-1-ylmethyl) ester (114044-39-2)

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 0.333333h;	A n/a B 80%

[fac-Mn(CO)3(1,2-bis(diphenylphosphino)ethane)(OH2)]BF4 (247939-31-7) + sodium succinate (150-90-3) → [(carbonyl)3 (bis(diphenylphosphino)ethan) manganese(I) (succinate) (manganese(I) (bis(diphenylphosphino)ethan) (carbonyl)3]

Conditions	Yield
In chloroform; water (Ar); sodium succinate dissolved in water; to CHCl3 soln. of (CO)3(dppe)Mn(OH2)BF4 equimolar quantity of new ligand added dropwise; stirring continued for 10-20 min; CHCl3 soln. separated; washed with water; dried and evaporated; resulting solids washed with hexane; dried in vacuo;	80%

gadolinium(III) nitrate hexahydrate + sodium succinate (150-90-3) → [Gd2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Gd salt with stirring for 10 min,heated for 24 h at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	80%

samarium(III) chloride hexahydrate + sodium succinate (150-90-3) → [Sm2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Sm salt with stirring, heated at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	80%

[2,2]bipyridinyl (366-18-7) + copper(II) nitrate trihydrate + sodium succinate (150-90-3) → [Cu2(succinate)(2,2'-bipyridyl)4](nitrate)2*10.5water

Conditions	Yield
In ethanol; water addn. of ethanolic soln. of bipyridine to aq. soln. of succinate salt toaq. soln. of copper compd., heating to 90°C; filtration, keeping at room temp. for 5 d with slow evapn., isolation ofcrystals, washing with cold water and ether, drying in open air, elem. anal.;	80%

sodium succinate (150-90-3) + benzoyl chloride (98-88-4) → benzoic acid anhydride (93-97-0) + benzoic acid (65-85-0)

Conditions	Yield
With Pyridine 1-oxide hydrochloride In dichloromethane; water at 18℃; Rate constant;	A 19% B 79%

tetra(thiourea)zinc chloride + sodium succinate (150-90-3) → di(thiourea)zinc (μ-succinate)

Conditions	Yield
In water 1 equiv. of ligand in H2O added to Zn complex in H2O; crystd. for several days, filtered, elem. anal., XRD, TGA;	78%

[2,2]bipyridinyl (366-18-7) + copper(II) nitrate trihydrate + sodium succinate (150-90-3) → [Cu2(μ-OH2)2(succinato)(2,2'-bipyridine)2(NO3)2](n)

Conditions	Yield
In methanol; water a MeOH soln. of 2,2'-bipyridine added dropwise to a MeOH soln. of Cu salt with stirring for 15 min, an aq. soln. of disodium succinate added slowly, refluxed for 2 h; cooled, filtered, kept in a CaCl2-desiccator for 7 d; elem. anal.;	78%

neodymium(III) nitrate hexahydrate + sodium succinate (150-90-3) → [Nd2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Nd salt with stirring, heated at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	78%

2,2'-biimidazole (492-98-8) + copper(II) nitrate trihydrate + sodium succinate (150-90-3) → [[Cu(2,2'-biimidazole)(H2O)(succinate)](H2O)]n

Conditions	Yield
In methanol; water 1 equiv. of Cu-salt in H2O was dropwise added to MeOH soln. of biimidazole-compd., 1 equiv. of aq. soln. of the Na-salt was added, reflux for 12h; cooling to room temp., soln. was filtered, filtrate was kept in a desiccator over CaCl2, crystn. for a few weeks, elem. anal.;	78%

cadmium(II) nitrate tetrhydrate + water (7732-18-5) + sodium succinate (150-90-3) + 2,5-bis-(4-pyridyl)-3,4-diaza-2,4-hexadiene → {[Cd(2,5-bis-(4-pyridyl)-3,4-diaza-2,4-hexadiene)(succinate)]·(H2O)3}n

Conditions	Yield
In methanol	78%

methanol (67-56-1) + copper(II) choride dihydrate + N,N'-bis[2-carboxybenzomethyl]-N,N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol + sodium succinate (150-90-3) + sodium hydroxide (1310-73-2) → 2Li(1+)*2Na(1+)*4Cu(2+)*2C31H29N4O5(3-)*2C4H4O4(2-)*2CH4O*10H2O*2Cl(1-)

Conditions	Yield
Stage #1: methanol; copper(II) choride dihydrate; N,N'-bis[2-carboxybenzomethyl]-N,N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol; sodium hydroxide at 20℃; for 1h; Stage #2: sodium succinate for 1h;	78%

zinc(II) nitrate hexahydrate + water (7732-18-5) + sodium succinate (150-90-3) + trans-1,2-bis(4-pyridyl)ethylene (1135-32-6) → {[Zn(succinate)(1,2-bis(4-pyridyl)ethylene)]2·(H2O)3}n

Conditions	Yield
In methanol	76%

1,10-Phenanthroline (66-71-7) + copper(II) tetrafluoroborate hydrate + sodium succinate (150-90-3) → [Cu8(succinato)4(1,10-phenanthroline)12](BF4)8*8H2O

Conditions	Yield
In methanol; water a MeOH soln. of 1,10-phenanthroline added dropwise to an aq. soln. of Cusalt with stirring for 15 min, an aq. soln. of disodium succinate added slowly, refluxed for 20 min; cooled, filtered, kept in a CaCl2-desiccator for 4 d; elem. anal.;	75%

europium(III) chloride hexahydrate + sodium succinate (150-90-3) → [Eu2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Eu salt with stirring, heated at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	75%

Glauber's salt + samarium(III) chloride hexahydrate + sodium succinate (150-90-3) → [Sm2(succinate)2(SO4)(H2O)2]

Conditions	Yield
In water at 175℃; for 24.5h;	75%

cadmium(II) nitrate tetrhydrate + water (7732-18-5) + sodium succinate (150-90-3) + N,N’-bis(1-pyridine-3-yl-ethylidene)hydrazine → {[Cd(2,5-bis-(3-pyridyl)-3,4-diaza-2,4-hexadiene)(succinate)]·(H2O)4}n

Conditions	Yield
In methanol	74%

1,2-bis(4'-pyridyl)ethane (4916-57-8) + cadmium(II) nitrate tetrhydrate + water (7732-18-5) + sodium succinate (150-90-3) → {[Cd3(1, 2-bis(4-pyridyl) ethane)3(succinate)2(H2O)2]·(NO3)2(H2O)4}n

Conditions	Yield
In methanol	74%

zinc(II) nitrate hexahydrate + water (7732-18-5) + sodium succinate (150-90-3) + 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene (13362-77-1) → {[Zn(succinate)(1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene)]·(H2O)2}n

Conditions	Yield
In methanol	71%

dysprosium(III) nitrate pentahydrate + sodium succinate (150-90-3) → [Dy2(succinato)3(H2O)2]*0.5H2O

Conditions	Yield
In water High Pressure; a soln. of Na salt added to a soln. of Dy salt with stirring, heated at 175°C; crystd. overnight by cooling to room temp.; elem. anal.;	70%

cobalt(II) chloride hexahydrate + sodium succinate (150-90-3) + p,p'-diaminobiphenyl (92-87-5) → [Co(benzidine)2(μ-succinate)(OH2)2]*(H2O)

Conditions	Yield
In methanol; water at 20℃;	70%

sodium succinate (150-90-3) + sodium D-gluconate (527-07-1) → trisodium 2-[(D-gluconate)-2-O-yl]butanedioate

Conditions	Yield
With lanthanum(III) chloride In water for 10.25h; Heating;	69.6%

zinc(II) nitrate hexahydrate + water (7732-18-5) + sodium succinate (150-90-3) + 4-pyridinealdazine (6957-22-8) → {[Zn4(1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene)2(succinate)3(OH)2]·5H2O}n

Conditions	Yield
In methanol	69%

Upstream product

• 25289-18-3 sodium glycolate 
• 3105-55-3 sodium maleate 
• 1070-34-4 butanedioic acid, monoethyl ester 
• 108-30-5 succinic acid anhydride 
• 110-15-6 succinic acid 
• 497-19-8 sodium carbonate 
• 305-72-6 α-ketoglutaric acid disodium salt 
• 140-99-8 calcium succinate 
• 556-32-1 magnesium succinate 
• 69361-29-1 succinic acid monopropyl ester sodium salt 
• 50888-28-3 succinic acid monomethyl ester sodium salt 
• 127-09-3 sodium acetate 

Downstream Products

• 480-97-7 4-hydroxybenzofuran 
• 2243-53-0 styrylacetic acid 
• 13389-88-3 5-oxo-2-phenyl-tetrahydro-furan-3-carboxylic acid 
• 13389-99-6 methyl trans-5-oxo-2-phenyltetrahydrofuran-3-carboxylate 
• 13389-88-3 (+/-)-5-oxo-2r-phenyl-tetrahydro-furan-3t-carboxylic acid 
• 766-39-2 2,3-Dimethylmaleic anhydride 
• 18434-42-9 bis-(3-phenyl-allylidene)-succinic acid anhydride 
• 75587-64-3 1,8-diphenylcyclooctatetraene 
• 5438-29-9 2-(3-nitro-phenyl)-5-oxo-tetrahydro-furan-3-carboxylic acid 
• 188290-36-0 thiophene 
• 288-05-1 selenophene 
• 108-30-5 succinic acid anhydride 
• 159389-76-1 calcium succinate monohydrate 
• 5908-80-5 succinic acid 

Related news

The study of phase behavior of aqueous 1-propanol/2-propanol/2-butanol/2-methyl-2-propanol systems in the presence of disodium tartrate or Disodium succinate (cas 150-90-3) at T=298.15K09/28/2019

Liquid–liquid equilibria (LLE) of the 1-propanol/2-propanol/2-butanol/2-methyl-2-propanol+disodium tartrate or disodium succinate+water systems have been measured at T=298.15K. The Merchuk et al. equation was used to correlate the obtained binodal data. The effect of some factors such as length...detailed

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