76529-99-2

Upstream product

• 6793-92-6 p-benzyloxyphenylbromide 
• 7579-36-4 dibenzyl oxalate 
• 108-95-2 phenol 
• 1198-84-1 4-hydroxymandelic acid 

Downstream Products

• 67509-39-1 benzyl O-benzyl-3-aminonocardicinate 
• 76529-92-5 (R)-(4-Benzyloxy-phenyl)-((S)-3-tert-butoxycarbonylamino-2-oxo-azetidin-1-yl)-acetic acid benzyl ester 
• 76529-95-8 (S)-(4-Benzyloxy-phenyl)-((S)-3-tert-butoxycarbonylamino-2-oxo-azetidin-1-yl)-acetic acid benzyl ester 
• 76530-01-3 benzyl -α-diazoacetate 

Relevant academic research and scientific papers

Butenolide derivative as well as preparation method and application thereof

The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.

Synthesis of vulpinic and pulvinic acids from tetronic acid

A common precursor, tetronic acid, was used in the synthesis of several vulpinic acids and pulvinic acids, which are pigments found in several lichens and mushrooms. The key features of this method are a two-step alkylidenation of benzyl tetronate and a Suzuki-Miyaura cross-coupling. The synthesis of several natural products, vulpinic acid, pinastric acid, xerocomic acid is described.