765292-65-7Relevant academic research and scientific papers
Vinylation of α-Aminoazoles with Triethylamine: A General Strategy to Construct Azolo[1,5-a]pyrimidines with a Nonsubstituted Ethylidene Fragment
Gao, Qinghe,Sun, Zhenhua,Xia, Qinfei,Li, Ruonan,Wang, Wenlong,Ma, Siwei,Chai, Yixin,Wu, Manman,Hu, Wei,ábrányi-Balogh, Péter,Keserü, Gy?rgy M.,Han, Xinya
supporting information, p. 2664 - 2669 (2021/04/12)
A new general synthesis of pharmaceutically important azolo[1,5-a]pyrimidines starting from widely available 3(5)-aminoazoles, aldehydes, and triethylamine is developed. The key is to enable the vinylation reaction that allows the in situ generation of elusive acyclic enamines and the subsequent annulation reaction to occur. This direct and practical strategy is capable of constructing a range of 5,6-unsubstituted pyrazolo[1,5-a]pyrimidines and [1,2,4]triazolo[1,5-a]pyrimidines. More importantly, this protocol provides a concise synthetic route to prepare the clinically used zaleplon.
Synthetic method of pyrazolopyrimidine compound
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Paragraph 0010; 0068-0070, (2021/06/12)
The invention discloses a synthesis method of a pyrazolopyrimidine compound, and belongs to the technical field of organic synthesis. According to the technical scheme, the method is characterized by comprising the following steps: dissolving an aldehyde
Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors
Gopalsamy, Ariamala,Ciszewski, Greg,Hu, Yongbo,Lee, Frederick,Feldberg, Larry,Frommer, Eileen,Kim, Steven,Collins, Karen,Wojciechowicz, Donald,Mallon, Robert
scheme or table, p. 2735 - 2738 (2009/12/31)
B-Raf kinase plays a critical role in the Raf-MEK-ERK signaling pathway and inhibitors of B-Raf could be used in the treatment of melanomas, colorectal cancer, and other Ras related human cancers. We have identified novel small molecule pyrazolo[1,5-a]pyr
Dihydropyrazolo[1,5-A]pyrimidine and dihydroimidazo[1,5-A]pyrimidine derivatives and methods of use thereof
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Page/Page column 11, (2008/06/13)
The present invention relates to dihydropyrazolo[1,5-a]pyrimidine and dihydroimidazo[1,5-a]pyrimidine derivatives, compositions comprising an effective amount of a dihydropyrazolo[1,5-a]pyrimidine or a dihydroimidazo[1,5-a]pyrimidine derivative and method
Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof
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Page/Page column 22, (2010/11/28)
The present invention relates to pyrazolo[1,5-a]pyrimidine derivatives, compositions comprising an effective amount of a pyrazolo[1,5-a]pyrimidine derivative and methods for treating or preventing cancer, comprising administering to a subject in need thereof an effective amount of a pyrazolo[1,5-a]pyrimidine derivative.
