76570-03-1Relevant articles and documents
Nickel-Catalyzed 1,2-Diarylation of Alkenyl Carboxylates: A Gateway to 1,2,3-Trifunctionalized Building Blocks
Derosa, Joseph,Kang, Taeho,Tran, Van T.,Wisniewski, Steven R.,Karunananda, Malkanthi K.,Jankins, Tanner C.,Xu, Kane L.,Engle, Keary M.
, p. 1201 - 1205 (2020)
A nickel-catalyzed conjunctive cross-coupling of alkenyl carboxylic acids, aryl iodides, and aryl/alkenyl boronic esters is reported. The reaction delivers the desired 1,2-diarylated and 1,2-arylalkenylated products with excellent regiocontrol. To demonstrate the synthetic utility of the method, a representative product is prepared on gram scale and then diversified to eight 1,2,3-trifunctionalized building blocks using two-electron and one-electron logic. Using this method, three routes toward bioactive molecules are improved in terms of yield and/or step count. This method represents the first example of catalytic 1,2-diarylation of an alkene directed by a native carboxylate group.
Lithium keten thioacetalides. Factors influencing α- versus γ-alkylation
Murphy, William S.,Wattanasin, Sompong
, p. 2678 - 2682 (2007/10/02)
Alkylation of the lithium salt of the vinyl-1,3-dithian (2; R = CH 3) occurred exclusively at the α-carbon. However both α- and γ-alkylation was observed with the substrate (2; R = C 6H5). A systematic investigation reveal
