7658-75-5

Basic information

• Product Name: Benzoic acid, 3,4,5-trimethoxy-, 2-(aminothioxomethyl)hydrazide
• CAS NO: 7658-75-5
• Molecular Formula: C11H15N3O4S
• Molecular Weight: 285.324
• Mol File: 7658-75-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,4,5-trimethoxy-, 2-(aminothioxomethyl)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,4,5-trimethoxy-, 2-(aminothioxomethyl)hydrazide(7658-75-5)
• EPA Substance Registry System: Benzoic acid, 3,4,5-trimethoxy-, 2-(aminothioxomethyl)hydrazide(7658-75-5)

Safety Data

• Hazardous Substances Data: 7658-75-5(Hazardous Substances Data)

Upstream product

• 118-41-2 Eudesmic acid 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 333-20-0 potassium thioacyanate 
• 3291-03-0 3,4,5-trimethoxybenzohydrazide 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 79-19-6 thiosemicarbazide 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 146942-59-8 3,4,5-Trimethoxy-benzoic acid N'-(4-methyl-thiazol-2-yl)-hydrazide 
• 14803-86-2 3-(3,4,5-trimethoxyphenyl)-4H-5-mercapto-1,2,4-triazole 
• 1673-43-4 2-amino-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole 
• 28004-59-3 2-(3,4,5-trimethoxyphenyl)-5-amino-1,3,4-thiadiazole 
• 140405-97-6 1-(4-Chloro-phenyl)-2-[5-(3,4,5-trimethoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethanone 
• 77803-73-7 ethyl 2-((5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate 
• 77803-55-5 2-((5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl)mercapto)acetic acid 
• 77803-67-9 6-(3,4,5-trimetossifenil)tiazolo<3,2-b>-s-triazol-3(2H)-one 
• 83805-45-2 2-(3,4,5-trimethoxyphenyl)-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole 
• 83796-54-7 2-(3,4,5-trimethoxyphenyl)hydrazine-1-carboxamide 
• 19938-46-6 2-acetamido-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole 
• 140423-95-6 3-(3,4,5-trimethoxyphenyl)-5-(4-bromophenyl)thiazolo<2,3-c>-s-triazole 
• 140405-71-6 2-(3,4,5-trimethoxyphenyl)-5-(4-bromophenyl)thiazolo<3,2-b>-s-triazole 
• 146942-43-0 3,4,5-Trimethoxy-benzoic acid N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazide 

Relevant articles and documents

Design and synthesis of 2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as α-glucosidase and α-amylase inhibitors, co-relative Pharmacokinetics and 3D QSAR and risk analysis

Ten fused heterocyclic derivatives bearing the 2,6-di(subsituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as central rings were synthesized and structures of the compounds were established by analytical and spectral data using FTIR, EI-MS, 1H NMR and 13C NMR techniques. In vitro inhibitory activities of synthesized compounds on α-amylase, α-glucosidase and α-burylcholinesterase (α-BuChE) were evaluated using a purified enzyme assays. Compound 5c demonstrated strong and selective α-amylase inhibitory activity (IC50?=?1.1?μmol/g). 5?g exhibited excellent inhibition against α-glucosidase (IC50?=?1.2?μmol/g) when compared with acarbose (IC50?=?4.7?μmol/g) as a positive reference. Compound 5i was found to be most potent derivative against α-BuChE with the IC50 of 1.5?μmol/g which was comparable to the value obtained for (4.7?μmol/g) positive control (i.e. galantamine hydrobromide). Molecular dockings of synthesized compounds into the binding sites of human pancreatic α-amylase, intestinal maltase-glucoamylase and neuronal α-butrylcholinesterase allowed to shed light on the affinity and binding mode of these novel inhibitors. Preliminary structure–activity relationship (SAR) studies were carried out to understand the relationship between molecular structural features and inhibition activities of synthesized derivatives. These data suggested that compounds 5c, 5?g and 5i are promising candidates for hitto- lead follow-up in the drug-discovery process for the treatment of Alzheimer's disease and hyperinsulinamia.

Synthesis and anti-microbial activity evaluation of some new 1-benzoyl-isothiosemicarbazides

The synthesis of some aroylisothiosemicarbazides was accomplished and their biological activity against bacteria, fungi, and mycobacteria was investigated. Different synthetic pathways were followed according to the kind of substituents that were introduced on both the aroyl ring and the sulfur atom. Anti-bacterial activity was measured against Staphylococcus aureus, S. epidermidis, Streptococcus agalactiae and S. faecalis, Escherichia coli, and Salmonella typhi, while antifungal activity was evaluated against C. albicans. Two species, Mycobacterium tuberculosis H37RV and Mycobacterium avium ATCC19421, were employed to evaluate antimycobacterial activity.

Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, corresponding 5-aryl-4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmacological interest

-