765948-79-6

Basic information

• Product Name: 1H-Isoindol-1-one, 4-(4-amino-2-fluorophenyl)-2,3-dihydro-
• Synonyms: 4-(4-Amino-2-fluoro-phenyl)-2,3-dihydro-isoindol-1-one
• CAS NO: 765948-79-6
• Molecular Formula: C14H11FN2O
• Molecular Weight: 242.253
• Mol File: 765948-79-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 546.8±50.0 °C(Predicted)
• Density: 1.325±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1H-Isoindol-1-one, 4-(4-amino-2-fluorophenyl)-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one, 4-(4-amino-2-fluorophenyl)-2,3-dihydro-(765948-79-6)
• EPA Substance Registry System: 1H-Isoindol-1-one, 4-(4-amino-2-fluorophenyl)-2,3-dihydro-(765948-79-6)

Safety Data

• Hazardous Substances Data: 765948-79-6(Hazardous Substances Data)

Usage

Structure

A derivative of isoindole with a fluorine-substituted phenyl group and an amino group

Appearance

White to off-white solid

Usage

As a precursor in the synthesis of pharmaceuticals and organic compounds

Potential applications

In medicinal chemistry and drug development due to structural features and potential biological activities

Additional research needed

To fully understand the properties and potential uses of the compound

Upstream product

• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 
• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 656-65-5 3-fluoro-4-bromophenylamine 
• 765948-78-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one 

Relevant articles and documents

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Isoindolinone ureas: A novel class of KDR kinase inhibitors

A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (50nM) and cellularly (≤100nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site.