765948-78-5

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-Dihydro-1H-isoindol-1-one-4-boronic acid pinacol ester is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity allows for the formation of complex molecular structures, contributing to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2,3-Dihydro-1H-isoindol-1-one-4-boronic acid pinacol ester is utilized as a building block for the creation of novel agrochemicals. Its ability to form carbon-carbon bonds is essential in the synthesis of pesticides and other agrochemicals that can enhance crop protection and yield.
Used in Organic Synthesis:
2,3-Dihydro-1H-isoindol-1-one-4-boronic acid pinacol ester is employed as a reagent in organic synthesis for the preparation of a wide range of organic compounds. Its boronic acid moiety facilitates the formation of carbon-carbon bonds, making it a crucial component in various chemical transformations and the synthesis of complex organic molecules.
Used in the Suzuki-Miyaura Cross-Coupling Reaction:
2,3-Dihydro-1H-isoindol-1-one-4-boronic acid pinacol ester is used as a reactant in the Suzuki-Miyaura cross-coupling reaction, a widely used method for forming carbon-carbon bonds. Its participation in this reaction is crucial for the synthesis of various organic compounds, including those with potential applications in materials science, pharmaceuticals, and agrochemicals.

Upstream product

• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 73183-34-3 bis(pinacol)diborane 
• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 

Downstream Products

• 765948-85-4 4-(4-amino-2-chlorophenyl)-1-isoindolinone 
• 765948-88-7 4-(4-amino-3,5-dimethyl-phenyl)-2,3-dihydro-isoindol-1-one 
• 765948-80-9 4-(4-amino-3-fluorophenyl)-1-isoindolinone 
• 765948-86-5 4-(4-amino-3-chlorophenyl)-1-isoindolinone 
• 765948-83-2 4-[4-amino-2-(trifluoromethyl)phenyl]-2,3-dihydro-isoindol-1-one 
• 765948-82-1 4-(4-amino-3-methyl-phenyl)-2,3-dihydro-isoindol-1-one 
• 765948-79-6 4-(4-amino-2-fluorophenyl)-1-isoindolinone 
• 765948-81-0 4-(4-amino-2-methylphenyl)-1-isoindolinone 
• 765948-84-3 4-[4-amino-3-(trifluoromethyl)phenyl]-1-isoindolinone 
• 765948-87-6 4-(4-amino-3-ethylphenyl)-1-isoindolinone 

Relevant academic research and scientific papers

CARBAZOLE COMPOUNDS AND METHODS OF USING SAME

The present invention provides carbazole compounds of the formula (I), which can be used for treating microbial, protozoan, viral infections and cancer. ?

FUSED INDOLE COMPOUNDS AND METHODS OF USING SAME

The invention relates to fused indole compounds of formula (I) that can be used for treating microbial infections, in particular, fungal infections, and selectively kill cancer cells.

CARBAZOLE COMPOUNDS AND METHODS OF USING SAME

The invention relates to carbazole compounds of formula (I) that can be used for treating microbial infections, in particular, fungal infections, and selectively kill cancer cells.

COMPOUNDS AND METHODS FOR TREATING CANCERS

Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine compounds. The compounds can be used to selectively kill cancer cells.

IMIDAZOLE DERIVATIVE

A CB2 receptor modulator comprising an imidazole derivative represented by the general formula (I): [wherein, R1 represents optionally substituted lower alkyl or the like; R2 represents optionally substituted cycloalkyl or the like; R3 represents optionally substituted aryl or the like; and n represents an integer of 0 to 3] or a pharmaceutically acceptable salt thereof as an active ingredient, and the like are provided.

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Isoindolinone ureas: A novel class of KDR kinase inhibitors

A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (50nM) and cellularly (≤100nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site.

ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.