765948-85-4

Usage

Type of compound

Heterocyclic compound with an isoindole core structure

Use in pharmaceutical industry

Building block for the synthesis of various drugs and bioactive compounds

Potential properties

Antifungal, antibacterial, and antitumor

Research subject

Cancer treatment

Upstream product

• 21402-26-6 4-bromo-3-chloroaniline 
• 765948-78-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one 
• 337536-15-9 4-bromo-2,3-dihydro-isoindol-1-one 
• 76006-33-2 3-bromo-2-methylbenzoic acid 
• 21900-48-1 3-bromo-2-methylbenzoic acid chloride 
• 99548-54-6 methyl 3-bromo-2-methylbenzoate 
• 337536-14-8 methyl 3-bromo-2-(bromomethyl)benzoate 

Relevant academic research and scientific papers

Isoindolinone kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Isoindolinone ureas: A novel class of KDR kinase inhibitors

A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (50nM) and cellularly (≤100nM). A 3D KDR/CDK2/MAP kinase overlay model with several structurally related tyrosine kinase inhibitors was used to predict the binding interactions of the isoindolinone ureas with the KDR active site.

ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS

Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.