76609-47-7

Usage

Uses

Used in Organic Chemistry:
4-(3-Picolyl)-3-thiosemicarbazide is used as a reagent in the synthesis of various compounds, leveraging its structural components to facilitate specific chemical reactions.
Used in Pharmaceutical Research:
4-(3-Picolyl)-3-thiosemicarbazide is used as a precursor in the development of pharmaceuticals, particularly for its potential biological activities such as antimicrobial, antiviral, and antitumor properties. The presence of the thiosemicarbazide group is known to contribute to these activities, making it a promising candidate for further research and development in medicinal chemistry.
Used in Chemical Reactions:
The picolyl group in 4-(3-Picolyl)-3-thiosemicarbazide is used to confer specific properties and reactivity to the compound, making it useful in certain chemical reactions where such characteristics are required for successful synthesis or transformation of other molecules.

InChI:InChI=1/C7H10N4S/c8-11-7(12)10-5-6-2-1-3-9-4-6/h1-4H,5,8H2,(H2,10,11,12)

Upstream product

• 36810-90-9 3-(isothiocyanatomethyl)pyridine 

Downstream Products

• 76609-54-6 C₂₀H₁₉N₅S 

Relevant academic research and scientific papers

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

In the area of cancer research, the development of new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic. The small molecule MIM1 has been reported earlier as one of the first selective inhibitors of the anti-apoptotic protein Mcl-1. In the present paper, we first revised the structure of this molecule based on extensive physicochemical analyses. Then we designed and synthesized a focused library of analogues for the corrected structure of MIM1. Next, these molecules were subjected to a panel ofin cellulobiological studies, allowing the identification of dual Bcl-xL/Mcl-1 inhibitors, as well as selective Mcl-1 inhibitors. These results have been complemented by fluorescence polarization assays with the Mcl-1 protein. Preliminary structure-activity relationships were discussed and extensive molecular modelling studies allowed us to propose a rationale for the biological activity of this series of new inhibitors, in particular for the selectivity of inhibition of Mcl-1versusBcl-xL

Synthesis of 4-Substituted Thiosemicarbazones of 3-Methyl-4-phenylpyridine-2-carboxaldehyde as Antitumor Agents

A convenient synthesis of 3-methyl-4-phenylpyridine-2-carboxaldehyde (4) is described.Reaction of 4 with 4-substituted thiosemicarbazides (6) gives thiosemicarbazones (7) some of which (7b, 7g, 7i and 7j) exhibit significant antitumor activity in animals.Thiosemicarbazides (6e - 6j) have been prepared from the corresponding isothiocyanates (5) (which result from sodium chlorite oxidation of the addition products of CS2 and the appropriate amine) and hydrazine.Isomerisation of 1,3-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine (Δ4-isomer) to 1,2,5,6-tetrahydro analog (Δ3-isomer, 1) has been effected with refluxing conc.HCl.