Welcome to LookChem.com Sign In|Join Free

CAS

  • or

36810-90-9

Post Buying Request

36810-90-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

36810-90-9 Usage

General Description

3-PICOLYL ISOTHIOCYANATE HYDROBROMIDE is a chemical compound that is used in organic synthesis and research. It is a derivative of isothiocyanate, which is known for its ability to react with nucleophiles in a variety of chemical reactions. The addition of a picolyl group to the isothiocyanate moiety provides a unique functional group that can be utilized in the development of complex molecules. The hydrobromide salt form makes the compound more stable and easier to handle in laboratory settings. 3-PICOLYL ISOTHIOCYANATE HYDROBROMIDE has potential applications in medicinal chemistry, drug discovery, and materials science, making it a valuable chemical for research and development purposes.

Check Digit Verification of cas no

The CAS Registry Mumber 36810-90-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,1 and 0 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 36810-90:
(7*3)+(6*6)+(5*8)+(4*1)+(3*0)+(2*9)+(1*0)=119
119 % 10 = 9
So 36810-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2S/c10-6-9-5-7-2-1-3-8-4-7/h1-4H,5H2

36810-90-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(isothiocyanatomethyl)pyridine

1.2 Other means of identification

Product number -
Other names 3-Pyridylmethyl isothiocyanate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36810-90-9 SDS

36810-90-9Relevant articles and documents

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Chen, Yun,Deng, Xianming,He, Hongbin,Hu, Zhiyu,Huang, Huiying,Jiang, Hua,Li, Li,Xu, Qingyan,Zhou, Rongbin

supporting information, (2020/02/15)

Aberrant activation of NLRP3 inflammasome is present in a subset of acute and chronic inflammatory diseases. The NLRP3 inflammasome has been recognized as an attractive therapeutic target for developing novel and specific anti-inflammatory inhibitors. Cellular structure-activity relationship-guided optimization resulted in the identification of 4-oxo-2-thioxo-thiazolidinone derivative 9 as a selective and direct small-molecule inhibitor of NLRP3 with IC50 of 2.4 μM, possessing favorable ex vivo and in vivo pharmacokinetic properties. Compound 9 may represent a lead for the development of anti-inflammatory therapeutics for treating NLRP3-driven diseases.

Systematic structure-activity relationship (SAR) exploration of diarylmethane backbone and discovery of a highly potent novel uric acid transporter 1 (URAT1) inhibitor

Cai, Wenqing,Wu, Jingwei,Liu, Wei,Xie, Yafei,Liu, Yuqiang,Zhang, Shuo,Xu, Weiren,Tang, Lida,Wang, Jianwu,Zhao, Guilong

, (2018/02/07)

In order to systematically explore and better understand the structure-activity relationship (SAR) of a diarylmethane backbone in the design of potent uric acid transporter 1 (URAT1) inhibitors, 33 compounds (1a-1x and 1ha-1hi) were designed and synthesized, and their in vitro URAT1 inhibitory activities (IC50) were determined. The three-round systematic SAR exploration led to the discovery of a highly potent novel URAT1 inhibitor, 1h, which was 200-and 8-fold more potent than parent lesinurad and benzbromarone, respectively (IC50 = 0.035 μM against human URAT1 for 1h vs. 7.18 μM and 0.28 μM for lesinurad and benzbromarone, respectively). Compound 1h is the most potent URAT1 inhibitor discovered in our laboratories so far and also comparable to the most potent ones currently under development in clinical trials. The present study demonstrates that the diarylmethane backbone represents a very promising molecular scaffold for the design of potent URAT1 inhibitors.

ISOTHIOCYNATES AND GLUCOSINOLATE COMPOUNDS AND ANTI-TUMOR COMPOSITIONS CONTAINING SAME

-

Paragraph 0095; 0103, (2013/05/21)

The present invention provides glucosinolate and isothiocyanate compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 36810-90-9