76609-54-6

Basic information

• Product Name: 3-methyl-4-phenylpyridine-2-carbaldehyde N-(pyridin-3-ylmethyl)thiosemicarbazone
• CAS NO: 76609-54-6
• Molecular Formula: C₂₀H₁₉N₅S
• Molecular Weight: 361.4634
• Mol File: 76609-54-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 557.7°C at 760 mmHg
• Flash Point: 291.1°C
• Density: 1.2g/cm³
• Vapor Pressure: 1.78E-12mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 3-methyl-4-phenylpyridine-2-carbaldehyde N-(pyridin-3-ylmethyl)thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-phenylpyridine-2-carbaldehyde N-(pyridin-3-ylmethyl)thiosemicarbazone(76609-54-6)
• EPA Substance Registry System: 3-methyl-4-phenylpyridine-2-carbaldehyde N-(pyridin-3-ylmethyl)thiosemicarbazone(76609-54-6)

Safety Data

• Hazardous Substances Data: 76609-54-6(Hazardous Substances Data)

Upstream product

• 76609-45-5 2-hydroxymethyl-3-methyl-4-phenyl-pyridine 
• 57420-12-9 3-methyl-4-phenylpyridine-2-carboxylic acid 
• 36810-90-9 3-(isothiocyanatomethyl)pyridine 
• 76609-46-6 3-methyl-4-phenylpyridine-2-carboxaldehyde 
• 76609-47-7 N-(pyridin-3-ylmethyl)hydrazinecarbothioamide 

Relevant articles and documents

Synthesis of 4-Substituted Thiosemicarbazones of 3-Methyl-4-phenylpyridine-2-carboxaldehyde as Antitumor Agents

A convenient synthesis of 3-methyl-4-phenylpyridine-2-carboxaldehyde (4) is described.Reaction of 4 with 4-substituted thiosemicarbazides (6) gives thiosemicarbazones (7) some of which (7b, 7g, 7i and 7j) exhibit significant antitumor activity in animals.Thiosemicarbazides (6e - 6j) have been prepared from the corresponding isothiocyanates (5) (which result from sodium chlorite oxidation of the addition products of CS2 and the appropriate amine) and hydrazine.Isomerisation of 1,3-dimethyl-4-phenyl-1,2,3,6-tetrahydropyridine (Δ4-isomer) to 1,2,5,6-tetrahydro analog (Δ3-isomer, 1) has been effected with refluxing conc.HCl.