7661-32-7

Basic information

• Product Name: 1-(4-BROMOPHENYL)-2-PYRROLIDINONE
• Synonyms: 2-pyrrolidinone, 1-(4-bromophenyl)-;1-(4-Bromophenyl)-2-oxopyrrolidine;3-(4-bromophenyl)pyrrolidin-2-one;BUTTPARK 32\07-61;1-(4-BROMOPHENYL)PYRROLIDIN-2-ONE;1-(4-BROMOPHENYL)-2-PYRROLIDINONE;1-(4-BROMOPHENYL)-2-PYRROLIDONE;1-(4-Bromophenyl)-2-pyrrolidinone, 99+%
• CAS NO: 7661-32-7
• Molecular Formula: C₁₀H₁₀BrNO
• Molecular Weight: 240.1
• Product Categories: Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 7661-32-7.mol
• Article Data: 25

Chemical Properties

• Melting Point: 98-101 °C
• Boiling Point: 98-101°C
• Flash Point: 98-101°C
• Appearance: Beige or faintly pink/Crystalline Powder
• Density: 1.4808 (rough estimate)
• Vapor Pressure: 2.27E-07mmHg at 25°C
• Refractive Index: 1.6120 (estimate)
• Storage Temp.: Room temperature.
• PKA: -0.32±0.20(Predicted)
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-2-PYRROLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-2-PYRROLIDINONE(7661-32-7)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-2-PYRROLIDINONE(7661-32-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 7661-32-7(Hazardous Substances Data)

Usage

Chemical Properties

Beige or faintly pink crystalline powder

InChI:InChI=1/C10H10BrNO/c11-8-3-5-9(6-4-8)12-7-1-2-10(12)13/h3-6H,1-2,7H2

Upstream product

• 4641-57-0 1-phenylpyrrolidin-2-one 
• 616-45-5 2-pyrrolidinon 
• 589-87-7 1,4-bromoiodobenzene 
• 22148-20-5 N-(4-bromophenyl)piperidine 
• 106-40-1 4-bromo-aniline 
• 300395-07-7 N-(4-bromophenyl)-4-chlorobutanamide 
• 14372-06-6 N-(4-bromophenyl)cyclopropanecarboxylic amide 
• 497-25-6 dimethylenecyclourethane 
• 41167-74-2 1-(4-bromophenyl)pyrrolidine-2,5-dione 

Downstream Products

• 196881-39-7 C₄₀H₄₅NO₇ 
• 22090-26-2 1-(4-bromo-phenyl)-pyrrolidine 
• 634903-74-5 N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[4-(2-oxo-1-pyrrolidinyl)phenyl]-1-benzothiophene-2-carboxamide hydrochloride 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles: Via the ring contraction and deformylative functionalization of piperidine derivatives

In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade reactions of N-substituted piperidines is presented. Mechanistically, the formation of pyrrolidin-2-ones involves a domino process including the in situ formation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation and ipso-oxidation. On the other hand, 3-iodopyrroles are believed to be formed via the initial generation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation, dehydrogenation, iodination and aromatization. Interestingly, either pyrrolidin-2-ones or 3-iodopyrroles could be obtained selectively from the same substrates, and the selectivity was easily tuned by using a specific oxidant and additive.

COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES

The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases