7661-44-1

Basic information

• Product Name: 3-Heptanone, 2-phenyl-
• CAS NO: 7661-44-1
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol File: 7661-44-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 3-Heptanone, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Heptanone, 2-phenyl-(7661-44-1)
• EPA Substance Registry System: 3-Heptanone, 2-phenyl-(7661-44-1)

Safety Data

• Hazardous Substances Data: 7661-44-1(Hazardous Substances Data)

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 34713-70-7 2-Phenylpropanal 
• 109-72-8 n-butyllithium 
• 39575-97-8 4,4,6-trimethyl-2-(1-phenyl-ethyl)-5,6-dihydro-4H-[1,3]oxazine 
• 17229-74-2 2,4-diphenyl-2H-isoxazol-5-one 
• 74-88-4 methyl iodide 
• 1068-55-9 isopropylmagnesium chloride 
• 25870-62-6 1-phenyl-2-hexanone 
• 100-42-5 styrene 
• 71-41-0 pentan-1-ol 
• 110-62-3 pentanal 
• 98-86-2 acetophenone 
• 83021-59-4 (Z)-hept-2-en-2-ylbenzene 
• 3156-07-8 methyl phenyl ketene 

Downstream Products

• 56844-77-0 2-Phenylheptan-3-ol 
• 56844-72-5 2-Phenylheptan-3-ol 
• 114634-24-1 (2S,3S)-2-Phenyl-3-trimethylsilanyl-heptan-3-ol 
• 97234-89-4 (Z)-2-phenyl-3-trimethylsilyloxy-3-heptene 
• 97234-87-2 (E)-2-phenyl-3-trimethylsiloxy-3-heptene 
• 97234-85-0 (E)-2-phenyl-3-trimethylsilyloxy-2-heptene 

Relevant articles and documents

Direct Synthesis of Mono-α-arylated Ketones from Alcohols and Olefins via Ni-Catalyzed Oxidative Cross-Coupling

Controlled synthesis of α-monoarylated ketones is significant yet challenging due to the site-selectivity issues and nonproductive overarylation reactions. Herein, we reported the direct synthesis of α-arylated ketones enabled by Ni-catalyzed dehydrogenative cross-coupling reaction cascade between alcohols and olefins. The use of readily available and cost-effective alcohols and olefins provides a straightforward access to monoarylated ketones in good yields with exclusive selectivity without using any advanced synthetic intermediates.

Complementary catalytic strategies to access α-chiral aldehydes

The present article summarizes the development of two novel and complementary catalytic methods to access α-chiral aldehydes. A C1-symmetric chiral (P,N) ligand with a structure derived from the ubiquitous binepine scaffold has been specifically designed for the Pd-catalyzed α arylation of aldehydes to access indane derivatives with a well-defined quaternary stereocenter in high yields and excellent enantioselectivities. In addition, a dinuclear palladium hydride catalyst has been synthesized for the isomerization of terminal and trisubstituted epoxides into aldehydes and ketones respectively. Combined experimental and theoretical investigations pointed to an unprecedented 'epoxide-opening/hydride-transfer' sequence. The mechanism also features two distinct enantio-determining steps in the kinetic resolution of racemic epoxides. Schweizerische Chemische Gesellschaft.

Biocatalysed concurrent production of enantioenriched compounds through parallel interconnected kinetic asymmetric transformations

Parallel interconnected kinetic asymmetric transformations were performed in order to obtain enantioenriched derivatives starting from a set of racemic or prochiral compounds. Thus, in a one-pot reaction using two redox biocatalysts (a BVMO and an ADH) and a catalytic amount of cofactor that acts as a mediator, enantioenriched ketones, sulfoxides, and sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.