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76634-99-6

76634-99-6

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  • 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8, 11-trihydroxy-8- (hydroxyacetyl)-1-methoxy-10-[[2,3, 6-trideoxy-3-[(1-oxododecyl)amino]-.alpha.-L-lyxohexopyranosyl]oxy ]-, (8S-cis)-

    Cas No: 76634-99-6

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  • 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-6,8, 11-trihydroxy-8- (hydroxyacetyl)-1-methoxy-10-[[2,3, 6-trideoxy-3-[(1-oxododecyl)amino]-.alpha.-L-lyxohexopyranosyl]oxy ]-, (8S-cis)- cas 76634-99-6

    Cas No: 76634-99-6

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76634-99-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 76634-99-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,6,3 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 76634-99:
(7*7)+(6*6)+(5*6)+(4*3)+(3*4)+(2*9)+(1*9)=166
166 % 10 = 6
So 76634-99-6 is a valid CAS Registry Number.

76634-99-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]dodecanamide

1.2 Other means of identification

Product number -
Other names (8S,10S)-10-((2R,4S,5S,6S)-4-(dodecanoylamido)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76634-99-6 SDS

76634-99-6Downstream Products

76634-99-6Relevant articles and documents

Fatty acyl amide derivatives of doxorubicin: Synthesis and in vitro anticancer activities

Chhikara, Bhupender S.,St. Jean, Nicole,Mandal, Deendayal,Kumar, Anil,Parang, Keykavous

, p. 2037 - 2042 (2011)

Doxorubicin is extensively used in anticancer therapy. Doxorubicin is highly hydrophilic, has short half-life, and its use is associated with severe side effects at high doses. Fatty acyl amide derivatives of doxorubicin were synthesized with the expectation to improve the lipophilicity and anticancer activity of the drug. The lipophilicity was enhanced with the increase in chain length of fatty acyl moiety. Conjugation of 4′-amino group with fatty acids through an amide bond reduced the anticancer activity in leukemia, breast, ovarian, and colon cancer cell lines, suggesting that the presence of free amino group is required for anticancer activity of doxorubicin. Dodecanoyl-doxorubicin derivative was consistently the most effective among the synthesized derivatives and inhibited the proliferation of colon (HT-29) and ovarian (SK-OV-3) cancer cells by 64% and 58%, respectively, at a concentration of 1 μM after 96 h incubation.

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