766519-08-8

Usage

Uses

Used in Pesticide Production:
(4-amino-2-methylphenyl)-carbamic acid propyl ester is used as an intermediate in the production of pesticides for its ability to be synthesized into various active ingredients that help control and manage pests in agriculture.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-amino-2-methylphenyl)-carbamic acid propyl ester is used as a building block for the synthesis of various medicinal compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
(4-amino-2-methylphenyl)-carbamic acid propyl ester is also utilized as a reagent in the synthesis of other organic compounds, highlighting its versatility in chemical reactions and its importance in the field of organic chemistry.

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Relevant academic research and scientific papers

Synthesis and structure-activity relationships of (aryloxy)quinazoline ureas as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors

In our continuing search for medicinal agents to treat proliferative diseases, quinazoline derivatives were synthesized and evaluated pharmacologically as epithelial growth factor receptor and vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitors. A quantitative structure-activity relationship analysis was conducted to rationalize the structure-activity relationship and to predict how similar the inhibitor-binding profiles of two protein kinases are likely to be on the basis of the docking of lead coumpounds into the ATP-binding site. This model was used to direct the synthesis of new compounds. A series of N-(aromatic)-N′-{4-[(6,7- dimethoxyquinazolin-4-yl)oxy]phenyl}urea were identified as potent and selective inhibitors of the tyrosine kinase activity of VEGFR-2 (fetal liver kinase 1, kinase insert domain-containing receptor). An efficient route was developed that enabled the synthesis of a wide variety of analogues with substitution on several positions of the template. Substitution of diarylurea, competitive with ATP, afforded several analogues with low nanomolar inhibition of enzymatic activity of VEGFR-2. In this paper, we describe the synthesis, structure-activity relationships, and pharmacological characterization of the series.

SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES

The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.