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Dendroxine is a novel chemical compound that has been developed for its potential therapeutic applications. It is a derivative of the naturally occurring compound dendrotoxin, which is found in the venom of the green mamba snake. Dendroxine has been engineered to selectively target and modulate the activity of voltage-gated potassium channels, particularly Kv1.1 and Kv1.2, which play a crucial role in neuronal excitability. This selective targeting allows dendroxine to potentially treat conditions characterized by hyperexcitability, such as certain neurological disorders. The compound's mechanism of action involves stabilizing the inactivated state of these potassium channels, thereby reducing the likelihood of neuronal firing. Research into dendroxine is ongoing, with the aim of understanding its full potential and safety profile for clinical use.

7668-77-1

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7668-77-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7668-77-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,6 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 7668-77:
(6*7)+(5*6)+(4*6)+(3*8)+(2*7)+(1*7)=141
141 % 10 = 1
So 7668-77-1 is a valid CAS Registry Number.

7668-77-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name dihydro-oxazolo[3',2':1,10]-14-nor-dendroban-12-one

1.2 Other means of identification

Product number -
Other names Dendroxin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7668-77-1 SDS

7668-77-1Downstream Products

7668-77-1Relevant academic research and scientific papers

Catalytic Enantioselective Total Synthesis of the Picrotoxane Alkaloids (-)-Dendrobine, (-)-Mubironine B, and (-)-Dendroxine

Guo, Lei,Frey, Wolfgang,Plietker, Bernd

, p. 4328 - 4331 (2018/07/29)

A concise enantioselective total synthesis of three sesquiterpenoid alkaloids - (-)-dendrobine, (-)-mubironine B, and (-)-dendroxine - is presented, which highlights the state-of-art catalytic methods, including enantioselective Diels-Alder cycloaddition, iron-catalyzed aerobic lactonization, copper-catalyzed cycloisomerization, and free-radical-initiated hydroazidation.

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