767289-08-7

Upstream product

• 19614-12-1 2-bromo-5-methoxybenzyl bromide 
• 74-89-5 methylamine 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 

Downstream Products

• 880105-01-1 4-methyl-benzenesulfinic acid (2-bromo-5-methoxy-benzyl)-methyl-amide 
• 205676-67-1 3-[N-(tert-butoxycarbonyl)-N-methylamino]methyl-4-bromoanisole 
• 1144029-15-1 C₁₂H₁₄BrNO₂ 
• 1148107-95-2 6-((2-bromo-5-methoxybenzyl)(methyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione 
• 1263788-28-8 C₁₈H₁₇BrN₂O₂ 
• 1520080-21-0 isopropyl 2-bromo-5-methoxybenzyl(methyl)carbamate 
• 205676-68-2 Methyl (+/-)-3-carbomethoxy-4-[2-[N-(tert-butoxycarbonyl)-N-methylamino]methyl-4-methoxyphenyl]butanoate 
• 205676-69-3 methyl (+/-)-3-carbomethoxy-4-[2-(methylamino)methyl-4-methoxyphenyl]butanoate 
• 767289-10-1 4-[N-methyl-N-(2'-bromo-5'-methoxybenzyl)]amino-6-tertiarybutylbenzopyran-7-one 

Relevant academic research and scientific papers

Smooth isoindolinone formation from isopropyl carbamates via bischler-napieralski-type cyclization

Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.

Intramolecular homolytic substitution of sulfinates and sulfinamides

A general and efficient method for the synthesis of cyclic sulfi-nates and sulfinamides based on intra-molecular homolytic substitution (SHi) at the sulfur atom by aryl or alkyl radi-cals is described. Both alkyl and benzo-fused compounds can be accessed di-rectly from easily prepared acyclic pre-cursors. Enantiomerically enriched sulfur-based heterocycles were formed through an SHi process with inversion of configuration at the sulfur atom. Cyclization of prochiral radicals proceeded with varying stereochemical outcomes, depending on the size of the incoming radical. 2-Pyridyl and 2-qui-nolyl radicals led to biaryl compounds, which result from attack onto the ortho position of the arylsulfinate rather than a thiophilic substitution.

Treatment Method

The present invention is directed to methods of treating an ocular neovascular disorder in a mammal by administration of pyrimidine derivatives, benzodiazepinyl derivatives and pharmaceutical compositions containing the same. The invention encompasses methods of treating an ocular neovascular disorder by administration of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, (S)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid or salts or solvates thereof. Combination therapies for the treatment of ocular neovascular disorders are also encompassed.