767321-32-4

Upstream product

• 2905-54-6 2,3-Dichlorobenzoic acid methyl ester 
• 206989-61-9 4-acetyl-1-(t-butoxycarbonyl)piperidine 

Downstream Products

• 550377-00-9 4-[5-(2,3-dichlorophenyl)-1-methyl-1H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 716371-44-7 4-[5-(2,3-dichlorophenyl)-2-methyl-2H-pyrazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 550377-03-2 [cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)