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2-(1,1-Dioxo-1H-1lambda6-benzo[d]isothiazol-3-ylamido)-ethanol, also known as 2-(1,1-dioxo-1lambda6-benzo[d]isothiazol-3-yl)-2-hydroxy-N,N-dimethylethanaminium, is a chemical compound with the molecular formula C11H12N2O3S. It is a derivative of benzo[d]isothiazole, a heterocyclic compound with a benzene ring fused to a diazole ring. This specific compound features a 2-hydroxyethylamine group attached to the benzo[d]isothiazole core, which is further oxidized to a 1,1-dioxide. It is commonly used as a reagent in various chemical reactions and as a building block in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical industries. Its unique structure and properties make it a versatile component in the development of new compounds with potential applications in various fields.

7677-49-8

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7677-49-8 Usage

Classification

Benzothiazole class of compounds

Applications

Industrial and scientific uses

Inhibition of PTP1B (Protein Tyrosine Phosphatase 1B)

Potent inhibitor

Potential treatment

Diabetes and obesity

Other properties

Antiviral, antitumor, and immune response modulation

Versatility

Diverse potential applications in pharmacology and biotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 7677-49-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,6,7 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7677-49:
(6*7)+(5*6)+(4*7)+(3*7)+(2*4)+(1*9)=138
138 % 10 = 8
So 7677-49-8 is a valid CAS Registry Number.

7677-49-8Downstream Products

7677-49-8Relevant academic research and scientific papers

Synthesis, characterization and antimicrobial evaluation of new 3-(Alkyl/Arylamino)benzo[d]isothiazole 1,1-derivatives

Kamble, Dhanraj P.,Shankarwar, Anil G.,Mane, Yogesh D.,Tigote, Radhakrishna M.,Sarnikar, Yuvaraj P.,Madje, Balaji R.

, p. 797 - 804 (2021/09/08)

The saccharine nucleus has long been recognized as a significant component in medicine. A series of pseudo-saccharine amines derivatives (7a-j) were synthesized and examined for their antibacterial activity. After testing all compounds, 7b, 7f, 7g, 7i and 7j were found most effective against Escherichia coli, Streptococcus aureus and Bacillus subtilis strains. The MIC of the compound was found from 4.6 to 16.1 μM. Further, compound 7f and 7i exhibited excellent activity against E.coli and Bacillus subtilis with MIC value 4.6 and 4.7 μM respectively. The compound 7b and 7i was found active against all the three bacteria. The zone inhibition was observed at 10 μM against Escherichia coli, Staphylococcus aureus and Bacillus subtilis at 0.9, 1.8, 3.9 respectively for 7b and 1.0, 1.8 and 2.0 cm respectively for 7i.

Saccharin Aza Bioisosteres - Synthesis and Preclinical Property Comparisons

Chen, Yantao,Aurell, Carl-Johan,Pettersen, Anna,Lewis, Richard J.,Hayes, Martin A.,Lepist?, Matti,Jonson, Anna C.,Leek, Hanna,Thunberg, Linda

supporting information, p. 672 - 677 (2017/06/13)

Saccharin is a well-known scaffold in drug discovery. Herein, we report the synthesis and preclinical property comparisons of three bioisosteres of saccharin: aza-pseudosaccharins (cluster B), and two new types of aza-saccharins (clusters C and D). We dem

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