76820-35-4

Usage

Uses

Used in Polymer and Resin Synthesis:
5-amino-N,N'-bis(2,3-dihydroxypropyl)isophthaldiamide is used as a key component in the production of various polymers and resins, particularly polyesters and polyurethanes, for its ability to enhance the properties of these materials.
Used in High-Performance Materials Development:
In the industry of high-performance materials, 5-amino-N,N'-bis(2,3-dihydroxypropyl)isophthaldiamide is used as a building block for creating adhesives, coatings, and other related products, due to its contribution to the improvement of material performance.
Used in Medical Applications:
5-amino-N,N'-bis(2,3-dihydroxypropyl)isophthaldiamide is being investigated for its potential use in medicine, specifically in drug delivery systems and tissue engineering, where its unique structure and properties could offer advantages in these fields.
Used in Pharmaceutical Industry:
5-amino-N,N'-bis(2,3-dihydroxypropyl)isophthaldiamide is used as a precursor in the synthesis of pharmaceutical compounds, leveraging its chemical properties to create new drugs with potential therapeutic benefits.
Used in Chemical Research:
In the field of chemical research, 5-amino-N,N'-bis(2,3-dihydroxypropyl)isophthaldiamide is used as a subject of study to explore its properties and potential applications, contributing to the advancement of scientific knowledge and the development of new technologies.

Upstream product

• 76820-34-3 5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide 
• 7440-05-3 palladium 
• 13290-96-5 dimethyl 5-nitroisophthalate 

Downstream Products

• 31127-80-7 N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide 
• 66108-95-0 iohexol 
• 92339-11-2 iodixanol 
• 76801-93-9 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide 

Relevant academic research and scientific papers

An intermediate of iodoxanol and a method for preparing iodixanol thereof

The present invention provides a method for preparing iodoxasol intermediates of iodoxaol, the intermediate formula VI of iodkesarol VI: 5,5'-[(2-hydroxy-1,3-propanedioxy)bis (acetylimino)] bis [N,N'-bis(2,3-dihydroxypropyl)-1,3-benzenedicarboxamide], iodized by formula VI to obtain iodoxaol finished products; the present invention provides a new synthetic idea of first forming a dimer and then iodizing, The prepared iodoxaol finished product: the total impurity content ≤ 1.0%, the impurity G content ≤0.5%; the method of the present invention has mild reaction conditions, low damage to the equipment, simple process, green environmental protection and low cost, can ensure the continuous production of high-quality products, has a high application value, suitable for industrial production.

Contrast medium of the impurity F synthetic method and its impurity G contrast medium, impurity H and impurity M application in the synthesis of

The invention relates to a synthesis method of contrast medium impurities, in particular to a contrast medium impurity F synthetic method and its in the contrast medium impurity G, impurity H and M application in the synthesis of the impurity, which belongs to the field of medical technology. The method is to 5 - nitro - 1, 3 - benzene dicarboxylic acid dimethyl ester (formula 2 compound) and 2, 3 - dihydroxy propylamine as raw materials of formula 3 compound, type 3 compound with hydrogen reduction reaction [...] 4 compound, of formula 4 with a compound obtained by reaction of the impurity F [...] contrast medium. The invention relates to 5 - nitro - 1, 3 - benzene dicarboxylic acid dimethyl ester (formula 2 compound) as the starting material, the synthesis of 5 - amino - N, double-N' - (2, 3 - dihydroxy-propyl) - diiodo - 1, 3 - benzene dicarboxylic amide (formula 1 compounds) and then to of formula 1 as the starting material for the synthesis of impurity G, impurity H and impurity M, for the contrast medium quality control to provide acceptable impurity reference substance.

IODINATION PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED-2,4,6-TRIIODO AROMATIC AMINES COMPOUNDS

The invention discloses a improved process for the preparation of 3,5-disubstituted- 2,4,6-triiodo aromatic amines of formula (II), wherein R1 and R2 are defined as herein. The compounds of formula (II) are the key intermediates for the synthesis of a series of non-ionic contrast agents such as Iopamidol, Iohexol and Iodixanol. The process comprises reacting chlorine-free iodinating reagents with 3,5-disubstituted-2,4,6-triiodo aromatic amines to obtain 3,5-disubstituted-2,4,6-triiodo aromatic amines of formula (II), wherein the molar yield of the iodination reaction can reach to 89%.

Process for the preparation of n,n-substituted 5-amino-1,3-benzenedicarboxamides

The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein R1 represents a straight or branched (C1-C4)-alkyl group, with at least the stoichiometric amount of an amine of formula H2NR.

New brominated compounds as contrast media for X-ray mammography

The invention regards new brominated compounds containing one or two phenyl rings with favorable physico-chemical properties, good tolerance profile, stability and suitable pharmacokinetic profile as contrast media for X-ray mammography, their pharmaceutical formulations and radiological application. The described new bromine contrast media will increase the sensitivity and specificity of X-ray mammography especially in problematic cases. The new contrast media have a higher X-ray absorption than iodine in the energy range used by mammography, a high hydrophilicity, lower toxicity and better tolerance profile than corresponding iodinated compounds.