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Product FOB Price Min.Order Supply Ability Supplier
5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Cas No: 31127-80-7
No Data 50 Gram 35 Metric Ton/Month Zhejiang Haizhou Pharmaceutical Co., Ltd. Contact Supplier
5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Cas No: 31127-80-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide CAS: 31127-80-7
Cas No: 31127-80-7
No Data 1 Metric Ton 1000 Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
5-acetamido-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
Cas No: 31127-80-7
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
5-Acetamido-N,N-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Cas No: 31127-80-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Cas No: 31127-80-7
USD $ 1.0-2.0 / Gram 10 Gram 200 Kilogram/Week Hubei Jusheng Technology Co., Ltd., Contact Supplier
CAS 31127-80-7 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Cas No: 31127-80-7
USD $ 1000.0-1000.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
Manufacturer supply CAS 31127-80-7 with best quality
Cas No: 31127-80-7
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
1,3-Benzenedicarboxamide,5-(acetylamino)-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- 31127-80-7
Cas No: 31127-80-7
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiono-1,3-benzenedicarboxamide CAS: 31127-80-7
Cas No: 31127-80-7
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier

31127-80-7 Usage

Chemical Properties

Whitye To Off-White Solid

Uses

An intermediate used in the synthesis of imaging agents such as Iohexol (I729500).

31127-80-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1344622)  Iohexol Related Compound A  United States Pharmacopeia (USP) Reference Standard 31127-80-7 1344622-100MG 14,578.20CNY Detail
Sigma-Aldrich (I0320810)  Iohexol impurity A  European Pharmacopoeia (EP) Reference Standard 31127-80-7 I0320810 1,880.19CNY Detail

31127-80-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

1.2 Other means of identification

Product number -
Other names 5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:31127-80-7 SDS

31127-80-7Synthetic route

5-acetamido-2,4,6-triiodo-1,3-phthalamide

5-acetamido-2,4,6-triiodo-1,3-phthalamide

epichlorohydrin
106-89-8

epichlorohydrin

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
Stage #1: 5-acetamido-2,4,6-triiodo-1,3-phthalamide; epichlorohydrin With 1-hexyl-3-methylimidazolium hexafluorophosphate at 80℃; for 3h;
Stage #2: With water at 30℃; for 5h; Reagent/catalyst; Temperature;
97%
5-acetamido-2,4,6-triiodoisophthaloyl dichloride
31122-75-5

5-acetamido-2,4,6-triiodoisophthaloyl dichloride

5-(acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide sodium salt

5-(acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide sodium salt

3-Amino-1,2-propanediol
616-30-8, 13552-31-3

3-Amino-1,2-propanediol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
With hydrogenchloride In methanol; water; 2,4-dichlorophenoxyacetic acid dimethylamine92%
iohexol
66108-95-0

iohexol

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
With lithium hydroxide In methanol92%
5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
76801-93-9

5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

acetic anhydride
108-24-7

acetic anhydride

A

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

B

3-(3-acetamido-5-((2,2-dimethyl-1,3-dioxolan-4-yl)methylcarbamoyl)-2,4,6-triiodobenzamido)-propane-1,2-diyl diacetate

3-(3-acetamido-5-((2,2-dimethyl-1,3-dioxolan-4-yl)methylcarbamoyl)-2,4,6-triiodobenzamido)-propane-1,2-diyl diacetate

C

5-acetamido-N,N′-bis-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl-2,4,6-triiodoisophthaldiamide

5-acetamido-N,N′-bis-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl-2,4,6-triiodoisophthaldiamide

D

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

E

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

Conditions
ConditionsYield
Stage #1: 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; acetic anhydride With toluene-4-sulfonic acid In acetone for 0.25h; Reflux;
Stage #2: With sodium hydroxide In water; acetone
A 70%
B 32%
C 17%
D n/a
E n/a
5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
76801-93-9

5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

acetic anhydride
108-24-7

acetic anhydride

A

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

B

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

C

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

3-acetamido-N-(2,3-dihydroxypropyl)-5-(5-hydroxymethyl-2,2-dimethyloxazolidine-3-carbonyl)-2,4,6-triiodobenzamide

Conditions
ConditionsYield
Stage #1: 5-amino-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; acetic anhydride With toluene-4-sulfonic acid In acetone for 0.25h; Reflux;
Stage #2: With sodium hydroxide In water; acetone
Stage #3: With sulfuric acid In water; acetone pH=0;
A 70%
B n/a
C n/a
5-Amino-N,N'-bis[2,3-dihydroxypropyl]-1,3-benzenedicarboxamide
76820-35-4

5-Amino-N,N'-bis[2,3-dihydroxypropyl]-1,3-benzenedicarboxamide

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Iodine monochloride / 6 h / 50 °C
2: sulfuric acid / water / 50 - 100 °C
3: sodium hydroxide; water / 20 °C / pH 9 - 11
View Scheme
5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide
76820-34-3

5-nitro-N,N'-bis-(2,3-dihydroxypropyl)isophthalamide

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5%-palladium/activated carbon; hydrogen / 70 °C / 9000.9 Torr / Autoclave
2: Iodine monochloride / 6 h / 50 °C
3: sulfuric acid / water / 50 - 100 °C
4: sodium hydroxide; water / 20 °C / pH 9 - 11
View Scheme
dimethyl 5-nitroisophthalate
13290-96-5

dimethyl 5-nitroisophthalate

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium methylate / methanol / 20 - 50 °C
2: 5%-palladium/activated carbon; hydrogen / 70 °C / 9000.9 Torr / Autoclave
3: Iodine monochloride / 6 h / 50 °C
4: sulfuric acid / water / 50 - 100 °C
5: sodium hydroxide; water / 20 °C / pH 9 - 11
View Scheme
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

epichlorohydrin
106-89-8

epichlorohydrin

A

iohexol
66108-95-0

iohexol

B

iodixanol
92339-11-2

iodixanol

Conditions
ConditionsYield
With hydrogenchloride; boric acid; potassium hydroxide In water pH=10 - 11; Product distribution / selectivity; Industry scale;A 7.5%
B 86.3%
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol at 45℃;
Stage #2: epichlorohydrin With hydrogenchloride In methanol at 20℃; for 48h; Product distribution / selectivity;
A 7.42%
B 52.1%
With hydrogenchloride; sodium hydroxide In water at 20℃; for 48h; pH=12.2 - 12.7;A 5.1%
B 43.5%
1-azido-2,3-epoxypropane
80044-09-3

1-azido-2,3-epoxypropane

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

C19H25I3N6O8
1309926-44-0

C19H25I3N6O8

Conditions
ConditionsYield
With boric acid; sodium hydroxide In methanol; water at 40℃; for 6h;70%
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

epichlorohydrin
106-89-8

epichlorohydrin

iodixanol
92339-11-2

iodixanol

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide In 2-methoxy-ethanol; water at 20℃; for 192h; Product distribution / selectivity;69.1%
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In 1-methoxy-2-propanol; water at 15 - 55℃;
Stage #2: epichlorohydrin With hydrogenchloride In 1-methoxy-2-propanol at 15℃; Product distribution / selectivity;
59.4%
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol at 45℃;
Stage #2: epichlorohydrin With hydrogenchloride In methanol at 10℃; for 48h;
46.8%
3-chloro-2-hydroxy-1-propyl acetate
24573-30-6

3-chloro-2-hydroxy-1-propyl acetate

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

3-(N-(2,5-bis((2,3-dihydroxypropyl)carbamoyl)-2,4,6-triiodophenyl)acetamido)--2-hydrooxypropylacetate

3-(N-(2,5-bis((2,3-dihydroxypropyl)carbamoyl)-2,4,6-triiodophenyl)acetamido)--2-hydrooxypropylacetate

Conditions
ConditionsYield
With sodium methylate In N,N-dimethyl acetamide at 20℃; for 18h; pH=11.5 - 12; pH-value; Reagent/catalyst; Solvent; Temperature;63%
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

tert-butyl N-(2-oxiranylmethyl)carbamate
148982-76-7, 149057-20-5, 115198-80-6

tert-butyl N-(2-oxiranylmethyl)carbamate

5-[Acetyl-(3-amino-2-hydroxy-propyl)-amino]-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-isophthalamide
1150307-23-5

5-[Acetyl-(3-amino-2-hydroxy-propyl)-amino]-N,N'-bis-(2,3-dihydroxy-propyl)-2,4,6-triiodo-isophthalamide

Conditions
ConditionsYield
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With potassium hydroxide In water; tert-butyl alcohol at 40℃;
Stage #2: With boric acid In water; tert-butyl alcohol
Stage #3: tert-butyl N-(2-oxiranylmethyl)carbamate With hydrogenchloride; potassium hydroxide more than 3 stages;
19%
With hydrogenchloride; potassium hydroxide; boric acid In water; tert-butyl alcohol19%
2-chloromethyl-2-methyloxiran
598-09-4

2-chloromethyl-2-methyloxiran

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

5,5'-(2-hydroxy-2-methylpropane-1,3-diyl)bis(acetylazanediyl)bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)
1186057-94-2

5,5'-(2-hydroxy-2-methylpropane-1,3-diyl)bis(acetylazanediyl)bis(N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)

Conditions
ConditionsYield
Stage #1: 2-chloromethyl-2-methyloxiran; N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With boric acid; potassium hydroxide In methanol; water at 20℃; pH=12.6 - 13;
Stage #2: With hydrogenchloride In methanol; water pH=4;
3%
1-chloro-3-methoxypropan-2-ol
4151-97-7

1-chloro-3-methoxypropan-2-ol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

A

N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxy-3-methoxypropyl)acetamido]-2,4,6-triiodoisophthalamide

N,N'-bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxy-3-methoxypropyl)acetamido]-2,4,6-triiodoisophthalamide

B

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N,N'-bis-(2,3-dihydroxy-propyl)-N-(2-hydroxy-3-methoxy-propyl)-2,4,6-triiodo-isophthalamide

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N,N'-bis-(2,3-dihydroxy-propyl)-N-(2-hydroxy-3-methoxy-propyl)-2,4,6-triiodo-isophthalamide

C

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N-(2,3-dihydroxy-propyl)-N'-[3-hydroxy-2-(2-hydroxy-3-methoxy-propoxy)-propyl]-2,4,6-triiodo-isophthalamide

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N-(2,3-dihydroxy-propyl)-N'-[3-hydroxy-2-(2-hydroxy-3-methoxy-propoxy)-propyl]-2,4,6-triiodo-isophthalamide

D

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N-(2,3-dihydroxy-propyl)-N'-[2-hydroxy-3-(2-hydroxy-3-methoxy-propoxy)-propyl]-2,4,6-triiodo-isophthalamide

5-[Acetyl-(2-hydroxy-3-methoxy-propyl)-amino]-N-(2,3-dihydroxy-propyl)-N'-[2-hydroxy-3-(2-hydroxy-3-methoxy-propoxy)-propyl]-2,4,6-triiodo-isophthalamide

Conditions
ConditionsYield
With sodium hydroxide; calcium chloride multistep reaction; cationic influence on the N/O alkylation selectivity; various metals chloride; var. concentr., var. reaction times and temperatures;A 83.85 % Chromat.
B n/a
C n/a
D n/a
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

5--N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
171897-76-0

5--N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide

5,5'-(N-acetyl-2-hydroxypropane-1,3-diyldiamino)bis

5,5'-(N-acetyl-2-hydroxypropane-1,3-diyldiamino)bis

Conditions
ConditionsYield
In water for 48h; Ambient temperature; pH=12.0;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

butan-1-ol
71-36-3

butan-1-ol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With sodium hydroxide; Ca(OH)2 In water
With sodium hydroxide; Ca(OH)2 In water
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

iohexol
66108-95-0

iohexol

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

oxiranyl-methanol
556-52-5

oxiranyl-methanol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With potassium hydroxide In methanol; dimethyl sulfoxide; isopropyl alcohol
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With boric acid; potassium hydroxide In water at 10℃; for 48h; pH=12.4;
Stage #2: oxiranyl-methanol In water at 10℃; for 24h; pH=12.6-13; Time; pH-value;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

3-monochloro-1,2-propanediol
96-24-2

3-monochloro-1,2-propanediol

iohexol
66108-95-0

iohexol

Conditions
ConditionsYield
With sodium methylate In propylene glycol
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In methanol; 1-methoxy-2-propanol at 25 - 45℃;
Stage #2: 3-monochloro-1,2-propanediol In methanol; 1-methoxy-2-propanol at 25℃; for 25.5h; Product distribution / selectivity;
Stage #1: N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With sodium hydroxide In 1-methoxy-2-propanol; water at 25 - 45℃;
Stage #2: 3-monochloro-1,2-propanediol In 1-methoxy-2-propanol; water at 35℃; for 27h; Product distribution / selectivity;
N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

Conditions
ConditionsYield
In methanol; chloroform
3.8 g (45%)
1,3-diiodo-2-(iodomethyl)propane
66587-78-8

1,3-diiodo-2-(iodomethyl)propane

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide
31127-80-7

N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide

tris(N-acetyl-N-(3,5-bis(2',3'-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl)aminomethyl)methane

tris(N-acetyl-N-(3,5-bis(2',3'-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl)aminomethyl)methane

Conditions
ConditionsYield
Stage #1: 1,3-diiodo-2-(iodomethyl)propane; N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide With potassium hydroxide; boric acid In methanol; water at 10 - 40℃; for 48h;
Stage #2: In methanol; water pH=3.5;

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