76833-51-7Relevant academic research and scientific papers
Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis
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, (2008/06/13)
Benzofuran derivatives, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic condit
Pharmaceutical heterocyclic compounds and compositions
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, (2008/06/13)
The compounds of the formula: STR1 wherein: R1, R2, R3, R4, R5 and R7, which may be the same or different, each represent hydrogen, hydroxy, alkyl or alkoxy of 1 to 6 carbon atoms, amino, acyl or acylamino of 2 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, halogen, or alkoxy of 1 to 6 carbon atoms substituted by phenyl, X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group, A is oxygen or is absent, Q represents a straight or branched alkylene, alkenylene or alkynylene group of 2 to 6 carbon atoms, and D represents carboxy, 5-tetrazolyl or carboxamido-5-tetrazolyl, and pharmaceutically acceptable salts, esters and amides thereof, are pharmaceutically active, being antagonists of the slow reacting substance of anaphylaxis (SRS-A) or its pathological effects. Pharmaceutical compositions containing the compounds are also described, as well as processes for preparing the compounds.
