76849-62-2Relevant academic research and scientific papers
Novel synthesis of N-alkyl amines from tandem coupling of either methylamine or nitroalkane with aldehyde
Lu, Shuanglong,Peng, Jie,Wu, Junjie,Li, Chao,Cao, Xueqin,Gu, Hongwei
supporting information, p. 760 - 763 (2016/01/12)
A novel tandem strategy for coupling of either methylamine or nitroalkane with aldehyde has been developed. This is the first demonstration that methylamine or nitroalkane is used as a methylation reagent, fabricating N-alkyl amines. The active Pt NWs allow for the selective preparation of a series of N-alkyl amines with good to excellent yields under mild and environmentally friendly conditions.
DETERMINATION OF THE CONFIGURATIONS OF ALCOHOLS AND ISOCYANATES BY KINETIC RESOLUTION
Potapov, V. M.,Gracheva, R. A.,Okulova, V. F.
, p. 311 - 316 (2007/10/02)
The kinetic resolution of α-phenylethyl isocyanate was achieved by means of R-α-phenylethylamine, and S-α-benzylethylamine, S-salsolidine.The absolute configuration of α-phenylisobutyl isocyanate was determined on the basis of the relationship discoverd during the kinetic resolution of the isocyanate with these amines.The configurations of the carbon atom carrying the hydroxyl group in the cis and trans isomer of 1,3-dimethyl-4-piperidol were determined as a result of investigation of the stereochemical relationships in the reaction of α-phenyl-ethyl isocyanatewith alicyclic alcohols.A new asymmetric catalyst (S-N-methyl-salsolidine) is proposed for the kinetic resolution of alkylphenylcarbinols with α-phenylethyl isocyanate.
