76858-80-5

Upstream product

• 66429-65-0 (6R)-7t-amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 70653-54-2 C₄₁H₃₈N₆O₁₀S 
• 66510-99-4 (6R,7R)-benzhydryl-7-amino-7-methoxy-3-((1-methyl-1H-tetrazol-5-ylthio)methyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 

Relevant academic research and scientific papers

Synthesis method of cefamoxef sodium

The invention relates to a synthesis method of latamoxef sodium. The synthesis method specifically comprises the following steps: reacting an oxygen cephalosporin mother nucleus 1 with 1-methyl-5-mercaptotetrazole sodium salt to obtain a compound 2, carrying out deprotection to obtain a compound 3, adding methoxyl and a 7-site side chain on the compound 3 to obtain a compound 5, and then, carryingout final deprotection on the compound 5 to obtain high-purity latamoxef sodium. The method provided by the invention is high in yield, mild in condition and environment-friendly; enzyme is used fordeprotection and condensation reaction, so that high-toxicity and high-corrosivity reagents are avoided; and the high-purity latamoxef sodium is obtained at a high yield.

Latamoxef intermediate solvate, preparation method and representation thereof

The invention provides a latamoxef sodium intermediate solvate, a preparation method and representation thereof. According to the invention, the latamoxef sodium intermediate ethyl acetate solvate product is high in purity, good in stability and easy to store; the preparation process is simple, solvate is separated out by adopting a recrystallization method, the yield is high, and the quality is stable; and the used crystallization reagent has low toxicity, is safer and more environment-friendly, and is suitable for large-scale production of latamoxef sodium.