7687-79-8

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Dichloro-5,6-dihydro-4H-cyclopenta[c]thiophen-4-one is used as a building block for the synthesis of various pharmaceutical products due to its potential biological activities and chemical versatility.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1,3-Dichloro-5,6-dihydro-4H-cyclopenta[c]thiophen-4-one serves as a key intermediate in the development of agrochemical products, contributing to its effectiveness and applicability in this field.
Used in Organic Synthesis:
1,3-Dichloro-5,6-dihydro-4H-cyclopenta[c]thiophen-4-one is used as a reagent in organic synthesis for the preparation of other organic compounds, highlighting its utility in creating a wide range of chemical entities.
Used in Research and Development:
1,3-Dichloro-5,6-dihydro-4H-cyclopenta[c]thiophen-4-one is also utilized in research and development settings for studying its potential as an anti-inflammatory and anti-cancer agent, given its noted biological activities and the ongoing quest for novel therapeutic agents.

Upstream product

• 7687-74-3 3-(2,5-dichlorothiophen-3-yl)propanoyl chloride 
• 10095-91-7 2,5-dichloro-3-chloromethyl-thiophene 
• 79-37-8 oxalyl dichloride 
• 7687-78-7 3-(2,5-dichlorothiophen-3-yl)propanoic acid 
• 16378-06-6 3-(3-thienyl)propanoic acid 
• 7695-30-9 2-(2,5-Dichloro-thiophen-3-ylmethyl)-malonic acid 
• 7687-77-6 (2,5-dichloro-thiophen-3-ylmethyl)-malonic acid diethyl ester 

Relevant academic research and scientific papers

CONDENSED THIOPHENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR (HIF) INHIBITORS

Compounds of the formula I in which R1, R2, R3, R4, R5, n and m have the meanings indicated in Claim 1, are inhibitors of HIF-2α, and can be employed for the treatment of diseases such as cancer.

THIOPHENE DERIVATIVES

Compounds of the formula (I) in which R1, R2, R3, R4 and n have the meanings indicated in Claim 1, are inhibitors of HIF-2α, and can be employed for the treatment of diseases such as cancer.

Pyridylfuran and pyridylthiophene compounds

A compound of the formula: and its pharmaceutically effective salts, wherein R1 and R2 are independently selected from the following: (a) hydrogen, halo, R5-, C2-6 alkenyl, C2-6 alkynyl, hydroxy-R5-, R5-O-R5-, or the like; (b) Ar-, Ar-R5-, Ar-C2-6 alkenyl, Ar-C2-6 alkynyl, Ar-O-, Ar-O-R5- or the like; (c) R5-C(O)-, -NO2, cyano, NH2-C(O)-, R5-NH-C(O)-, (R5)2-N-C(O)-, Ar-C(O)- or the like; and (d) R5-C(O)-NH-, Ar-C(O)-NH- or the like; wherein Ar is optionally substituted aryl or heteroaryl such as phenyl and pyridyl; and wherein R5 is optionally halo-substituted C1-6 alkyl; R3 is selected from the following: (e) cyano, formyl, tetrazolyl, triazolyl, imidazolyl, oxazolyl, thiazolyl, R5-C(O)-, C2-6 alkenyl-C(O)-, C2-6 alkynyl-C(O)-, R5-C(O)-R5-, or the like; (f) R5-C(O)-NH-, Ar-C(O)-NH-, or the like; (g) R5-S-, R5-S(O)-, R5-NH-S(O)2-, or the like; and (h) Ar-C(O)-, Ar-R5-C(O)-, Ar-C2-6 alkenylene-C(O)- or the like; or two of R1, R2 and R3 together form a group of the formula -A1-B1-A2- or -A1-B1-A3-B2-A2- such as cyclic alkyl optionally substituted with oxo; R4 is hydrogen, halo, R5-C(O)- and the like; X is O, S, S(O) or S(O)2; m is 0, 1, 2, 3 or 4. The present invention also provides processes for the preparation thereof, the use thereof in treating cytokine mediated diseases and/or cell adhesion molecule (CAM) mediated diseases and pharmaceutical compositions for use in such therapy.

REDUCTION DES CONTRAINTES STERIQUES (EMPECHEMENT A LA CONJUGAISON) DANS LES POLY(DIALKYL-3,4-THIOPHENES)

Cyclopenta thiophene, cyclopenta thiophene and thieno thiophene have been synthesized.The electropolymerization of these monomers was attempt.The electrical properties of poly(cyclopenta thiophene) are intermediate between those of poly(3-methylthiophene) and poly(3,4-dimethyl thiophene).