76877-76-4Relevant academic research and scientific papers
Synthesis of cyclic hydroxamic acids from aliphatic nitro compounds
Thomas, Achamma,Rajappa, Srinivasachari
, p. 10571 - 10580 (2007/10/02)
A novel method for the synthesis of five membered α-substituted cyclic hydroxamic acids from aliphatic nitro compounds including nitro acetic acid derivatives is described. Michael addition of allyl acrylate to these compounds followed by Pd(0) catalyzed
Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents
Mimura,Hayashida,Nomiyama,Ikegami,Iida,Tamura,Hiyama,Ohishi
, p. 1971 - 1986 (2007/10/02)
Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.
Producing substituted 2-cyclopentenones
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, (2008/06/13)
A process is provided for producing substituted 2-cyclopentenones represented by the general formula: STR1 where R1, R2, R3, R4, and R5 are hydrogen or lower aliphatic hydrocarbyl groups. The process comprises treating a nitroalkane with a substituted acrylic acid ester in the presence of a base, followed by saponification, to yield a substituted 4-nitropentanoic acid which acid is then treated with strong acid under dehydrative conditions to yield the subject 2-cyclopentenone.
