180-73-4

Usage

Chemical class

Spiro compounds

Bicyclic structure

Contains a spiro carbon atom and a nitrogen atom

Pharmaceutical industry use

Building block for the synthesis of various bioactive compounds and drugs

Potential application

As a ligand in asymmetric catalysis

Biological activities

Exhibits interesting biological activities, valuable for medicinal chemistry research

Fragrance industry use

Shown promise for use as an odorant due to its unique structure and aromatic properties

Upstream product

• 56139-90-3 1-azaspiro[5.5]undecan-2-one 
• 1122-60-7 1-nitrocyclohexane 
• 155137-19-2 4-(1-Amino-cyclohexyl)-butyric acid ethyl ester 
• 5498-73-7 3-(1-nitro-cyclohexyl)-propionic acid ethyl ester 
• 627-27-0 homoalylic alcohol 
• 108-91-8 cyclohexylamine 
• 100453-64-3 4-(1-nitro-cyclohexyl)-butyric acid ethyl ester 
• 144230-49-9 3-(1-nitro-cyclohexyl)-propionyl chloride 
• 76877-76-4 3-(1-nitrocyclohexyl) propionic acid 

Relevant academic research and scientific papers

Synthesis of secondary amines by titanium-mediated transfer of alkenyl groups from alcohols

Reaction of Ti(NMe2)4 with allyl alcohols and primary amines leads to the selective formation of secondary allylic amines. The allyl transfer from the alcohol to the amine occurs with selective allylic transposition. Due to substituent effects in the reactions, we postulate that the reaction occurs through a [2 + 2]/retro-[2 + 2]-cycloaddition mechanism. It was also found that a similar reaction could be accomplished with homoallylic alcohol. In this case, the more complex mechanism leads to the formation of 1-aza-spiro[5.5]undecane. Possible pathways for the homoallylic transfer and cyclization are discussed. Copyright

Bisphosphonic acid derivatives, as bone resorption inhibitors

A bisphosphonic acid derivative of the formula (I) or a pharmaceutically acceptable salt thereof: STR1 wherein A is STR2 each of R3 and R4, which may be the same or different, is (i) a hydrogen atom, (ii) a C1-6 alkyl grou

Synthesis and evaluation of (piperidinomethylene)bis(phosphonic acid) derivatives as anti-osteoporosis agents

Some (piperidinomethylene)bis(phosphonic acid) derivatives were prepared and their activity to inhibit a rise in serum calcium induced by parathyroid hormone in thyroparathyroidectomised rats was evaluated. Several (4- alkylidene-, 4,4-dialkyl-, or 4-alkyl-4- halopiperidinomethylene)bis(phosphonic acid) derivatives showed considerable inhibitory activity. But compounds having aromatic and polar substituents such as azido, hydroxy, amino and amido on the piperidine ring were generally inactive. In this study, two 4-alkylidene compounds (8a and 8b) and a 4,4- cyclic dialkyl compound (61) showed potent activity when administered either intravenously or perorally.