76885-97-7Relevant academic research and scientific papers
Decoding the logic of the tRNA regiospecificity of nonribosomal femX Wv aminoacyl transferase www.angewandte.org
Fonvielle, Matthieu,Chemama, Maryline,Lecerf, Maxime,Villet, Regis,Busca, Patricia,Bouhss, Ahmed,Etheve-Quelquejeu, Melanie,Arthur, Michel
experimental part, p. 5115 - 5119 (2010/11/04)
Natural selection: Replacement of the 3′-OH group of Ala-tRNA Ala with 3′-H affected FemXWv-catalyzed aminoacyl transfer from the 2 -position, but not substrate binding. The ability of FemXWv to bind and transacylate the 3′-O-Ala isomer initially formed by alanyl-tRNA synthetase (AlaRS) may be crucial for efficient competition with the ribosome (see scheme). (Figure Presented).
SYNTHESIS AND PROPERTIES OF 3'-DEOXYADENYLATE TRIMER dA2'p5'A2'P5'A
Charubala, Ramamurthy,Pfleiderer, Wolfgang
, p. 4077 - 4080 (2007/10/02)
The trimeric 3'-deoxyadenylyl-(2'->5')-3'-deoxyadenylyl-(2'->5')-3'-deoxyadenosine (12) was synthesized via the phosphotriester approach starting from cordycepine (1).Various physical data have been determined and compared with those of the ribo-A2'p5'A2'p5'A analog.
