76915-53-2Relevant academic research and scientific papers
Novel heterocyclic derivative capable of being used as SHP2 inhibitor
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Paragraph 0310, (2019/08/30)
The invention relates to a novel heterocyclic derivative capable of being used as an SHP2 inhibitor, specifically relates to a compound shown by a formula I or pharmaceutically acceptable salts thereof, further relates to a use of the compound shown by the formula I or the pharmaceutically acceptable salts thereof and a pharmaceutical composition thereof in drug preparation, and particularly relates to a use in preparation of drugs for treatment, inhibition or prevention of diseases or discomforts mediated by SHP2 activity.
NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS
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Page/Page column 66, (2018/10/19)
This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.
Regioselectivity in free radical bromination of unsymmetrical dimethylated pyridines
Thapa, Rajesh,Brown, Jordan,Balestri, Thomas,Taylor, Richard T.
supporting information, p. 6743 - 6746 (2015/01/09)
During a literature review some curious inconsistencies in the free radical bromination of picolines were noted. To achieve a better understanding of the mechanisms and regioselectivity we reran these reactions, extending our work to unsymmetrical lutidin
Synthesis of Functionalized Quinoline Derivatives by Annulation of Pyridines
Ghera, Eugene,David, Yoshua Ben,Rapoport, Henry
, p. 2059 - 2065 (2007/10/02)
Thiophenyl and sulfonylphenyl groups were introduced on each methyl group of 2,3-lutidine (1), and the reactivity of the adjacent carbanions has been examined.When both methyl groups of 1 were substituted with sulfur groups, regioselective alkylation of t
