76918-59-7

Basic information

• Product Name: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester
• Synonyms: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester
• CAS NO: 76918-59-7
• Molecular Weight: 378.302
• Mol File: 76918-59-7.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester(76918-59-7)
• EPA Substance Registry System: (R)-2-((R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester(76918-59-7)

Safety Data

• Hazardous Substances Data: 76918-59-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 70681-41-3 (R)-dimethyl malate 

Relevant articles and documents

Sesquiterpene dimers esterified with diverse small organic acids from the seeds of Sarcandra glabra

11 new sesquiterpene dimers, sarglabolides A-K (1-11), and five known ones were isolated from the seeds of Sarcandra glabra. Their structures were elucidated by spectroscopic data analysis and chemical evidence. Sarglabolide A (1) was verified to exclusively possess a seventeen-membered macrocyclic ester ring formed by the scaffold of the sesquiterpene dimer and small organic acids, different from the eighteen-membered rings of the other reported analogues. The chiral small organic acid moieties were assigned to l-malic acid, d-malic acid, and d-tartaric acid based on the combination of spectroscopy, chemical derivatization and HPLC analysis. Dimers 1, 12 and 13 can significantly inhibit NO production in LPS-induced macrophages with IC50 values at 3.04, 4.65 and 2.33 μmol/L, respectively.