76947-33-6

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 583-60-8 2-Methylcyclohexanone 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 36065-27-7 N-α-phenylethylacetamide 
• 76947-34-7 N-(2-Methyl-cyclohex-1-enyl)-N-(1-phenyl-ethyl)-acetamide 
• 118664-19-0 (4R,4aS)-4,4a-Dimethyl-1-((R)-1-phenyl-ethyl)-3,4,4a,5,6,7-hexahydro-1H-quinolin-2-one 
• 118664-18-9 (4R,4aS,8aR)-4,4a-Dimethyl-2-oxo-1-((R)-1-phenyl-ethyl)-octahydro-quinoline-8a-carbonitrile 
• 118664-20-3 (S)-3-((S)-1-Methyl-2-oxo-cyclohexyl)-2-phenylsulfanyl-propionic acid methyl ester 
• 53068-89-6 (R)-(+)-2-(2'-carbomethoxyethyl)-2-methylcyclohexanone 
• 53068-89-6 (S)-3-(1-methyl-2-oxocyclohexyl)-propionic acid methyl ester 
• 91603-25-7 (αR,1R,2S)-(+)-cis-2-Methyl-N-(1-phenylethyl)cyclohexanamin-hydrochlorid 
• 1263420-10-5 4-((1R,2S)-2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carbonitrile 
• 1263419-13-1 4-((1R,2S)-2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-24-4 6-amino-4-((1R,2S)-2-methylcyclohexylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-23-3 4-((1R,2S)-2-methylcyclohexylamino)-6-nitropyrrolo[1,2-b]pyridazine-3-carboxamide 
• 1263419-22-2 4-((1R,2S)-2-methylcyclohexylamino)-6-nitropyrrolo[1,2-b]pyridazine-3-carbonitrile 
• 79389-41-6 (1R,2S)-(+)-cis-2-Methyl-cyclohexanamin-hydrochlorid 

Relevant academic research and scientific papers

PYRROLO [1, 2-B] PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS

The invention provides compounds of formula l: ( I ) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula I.

A practical strategy for the structural diversification of aliphatic scaffolds through the palladium-catalyzed picolinamide-directed remote functionalization of unactivated C(sp3)-H bonds

Hats off to the director: High levels of regio- and stereoselectivity were observed for a broad range of amine substrates with aryl and vinyl iodide coupling partners in the title reaction. The synthetic utility of this strategy was highlighted by the rea

Determination of the conformations and relative configurations of exocyclic amines

The conformations and relative configurations of 20 amines, classified according to the following labeling scheme, were analyzed. Series a comprised compounds derived from N-(1-phenylethyl)cyclohexanamine, b comprised derivatives of N-[1-(naphthalen-2-yl)ethyl]cyclohexanamine, c comprised derivatives of N-(diphenylmethyl)cyclohexanamine, and d comprised derivatives of N-(propan-2-yl)cyclohexanamine. The compounds were labeled as follows: 1 indicates cyclohexanamine, 2 indicates 2-methylcyclohexanamines, 3 indicates 3-methylcyclohexanamines, 4 indicates 4-methylcyclohexanamines, and 5 indicates 4-tert-butylcyclohexanamines. These compounds were prepared without the use of stereoselective induction and, therefore, all expected stereoisomers were observed. Structural assignments were established by 1H, 13C, and 15N NMR.