76953-98-5

Upstream product

• 106-39-8 bromochlorobenzene 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 99-91-2 para-chloroacetophenone 
• 69843-10-3 1-chloro-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 917-64-6 methyl magnesium iodide 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 

Downstream Products

• 69843-10-3 1-chloro-4-(1,1,1-trifluoroprop-2-en-2-yl)benzene 
• 122243-10-1 3-Nitro-benzenesulfonic acid 1-(4-chloro-phenyl)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 76954-01-3 2-(3'-chlorophenyl)-1,1,1-trifluoro-2-propyl tosylate 

Relevant academic research and scientific papers

Trifluoromethyl reagent as well as synthesis method and application thereof

The invention discloses a trifluoromethyl reagent as well as a synthesis method and application thereof, wherein the structural formula of the trifluoromethyl reagent is as shown in formula I in the specification. According to the invention, diphenyl trifluoromethylphosphine and iodomethane are used as raw materials, and are heated in an organic solvent to carry out an addition reaction to prepare the trifluoromethylation reagent. The method is simple and convenient in process, high in yield and capable of realizing 10-gram-level large-scale preparation; more importantly, the trifluoromethylation reagent can be used as a free radical and a nucleophilic reagent to be applied to free radical addition reaction and simple nucleophilic addition reaction to prepare different types of trifluoromethylation products, so that the method has important application value.

PREPARATION PROCESS OF PERFLUOROALKYL COMPOUND WITH MONOHYDROPERFLUOROALKANE AS STARTING MATERIAL

A simple production process is provided of a perfluoroalkyl compound that uses monohydroperfluoroalkane as a starting material, the perfluoroalkyl compound being an important intermediate of organic electronic materials, medicine, agricultural chemicals,

P - [...] mono hydro pell fluoro alkane derivative as a starting material and method for producing a perfluoroalkyl compounds or derivatives [...] p - (by machine translation)

[Problem] to the para position of the benzene ring of the benzaldehyde derivative having a halogen atom or a phenyl ketone carbonyl group with a mono hydro pell fluoro alkane as a starting raw material, an organic material, a pharmaceutical, an agrochemical, a polymeric material such as a function of the important intermediate for the production of perfluoroalkyl compounds is simple. The following reaction schemes are illustrated in schemes [a], (1a) mono hydro pell fluoro alkane basic action, in addition to the benzene ring of the benzaldehyde derivative having a halogen atom or a phenyl ketone carbonyl group in the para position by reaction, and a benzene ring (2a) having a perfluoroalkyl group having a halogen atom at the para position of alcohol production. [Drawing] no (by machine translation)

Trifluoromethylation of ketones and aldehydes with Bu3SnCF 3

The (trifluoromethyl)stannane reagent, Bu3SnCF3, was found to react under CsF activation with ketones and aldehydes to the corresponding trifluoromethylated stannane ether intermediates at room temperature in high yield. Only a mildly acidic extraction (aqueous NH 4Cl) is required to release the corresponding trifluoromethyl alcohol products. The protocol is compatible with acid-sensitive functional groups.

β-DEUTERIUM KINETIC ISOTOPE EFFECTS IN THE SOLVOLYSIS OF 2-ARYL-1,1,1-TRIFLUORO-2-PROPYL TOSYLATES AND OF 2-ARYL-2-PROPYL p-NITROBENZOATES. EVIDENCE FOR A VARIATION OF THE CONTRIBUTION OF α-METHYL SUBSTITUENT IN STABILIZING CATIONIC REACTION CENTERS WITH DIFFERENT ELECTRON DEMAND

A very high β-deuterium kinetic isotope effect, k(CH3)/k(CD3)=2.13 at 60 deg C, was found for the solvolysis of 2-(3'-chlorophenyl)-1,1,1-trifluoro-2-propyl tosylate (2c) and the α-CD3 analogue (4c), and the effect decreased with increasing electron attracting of the substituent on the aromatic ring which showed the variation of the contribution of α-methyl group to the stabilization of the cationic reaction center in the transition state.

Solvolytic Studies of the Highly Deactivated 1-Aryl-1-(trifluoromethyl)ethyl Tosylates

The rates of solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates 1b-i and 1-aryl-1-(trifluoromethyl)ethyl bromides 3a,b in 80percent ethanol, and of 1-phenyl- and 1-(3-chlorophenyl)-1-(trifluoromethyl)ethyl tosylates (1e and 1g) in a variety of solven

SOLVOLYSIS OF 1-ARYL-1-(TRIFLUOROMETHYL)ETHYL TOSYLATES. EVIDENCE FOR AN EXTREMELY HIGH ELECTRON DEMAND CARBENIUM ION INTERMEDIATE DUE TO THE PRESENCE OF α-TRIFLUOROMETHYL SUBSTITUENT

The rate-retarding effect of α-trifluoromethyl group observed in the solvolysis of 1-aryl-1-(trifluoromethyl)ethyl tosylates is so profound that a very large negative ρ+ value, -8.82, is resulted and the 1-phenyl derivative becomes even less re