76969-81-8

Usage

Uses

Used in Pharmaceutical Industry:
(2-Chloro-acetylamino)-acetic acid methyl ester is used as a building block for the synthesis of more complex molecules, particularly in the development of pharmaceuticals. Its unique structure allows it to be a key component in creating new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, (2-Chloro-acetylamino)-acetic acid methyl ester serves as an important intermediate for creating a variety of organic compounds. Its versatility in chemical reactions makes it a valuable asset in the synthesis of various organic molecules.
Used in Agrochemical Manufacturing:
(2-Chloro-acetylamino)-acetic acid methyl ester may have potential use as a chemical intermediate in the manufacturing of agrochemicals. Its properties could contribute to the development of new pesticides, herbicides, or other agricultural products to improve crop yields and protect plants from pests.
Used in Specialty Chemicals Production:
(2-CHLORO-ACETYLAMINO)-ACETIC ACID METHYL ESTER also has potential applications in the production of specialty chemicals, where its unique characteristics can be utilized to create specific chemical products for various industries, such as coatings, adhesives, or textiles.
As with any chemical compound, proper handling and safety precautions should be taken when working with (2-Chloro-acetylamino)-acetic acid methyl ester to ensure the safety of individuals and the environment.

InChI:InChI=1/C5H8ClNO3/c1-10-5(9)3-7-4(8)2-6/h2-3H2,1H3,(H,7,8)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 79-11-8 chloroacetic acid 

Downstream Products

• 6319-96-6 N-(chloroacetyl)glycine 

Relevant academic research and scientific papers

PRODRUGS OF ABIRATERONE

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers, or pharmaceutically acceptable salt(s) thereof as prodrugs of abiraterone. The present invention also describes method of making such compounds, pharmaceutical compositions comprising such compounds and the use of the compounds of formula (I).

PROCESS FOR PREPARING RHODANINE-3-ACETIC ACID: A KEY INTERMEDIATED OF EPALRESTAT

A process for preparation of (4-oxo-2-thioxo-1,3-thiazolidin-3-yl) acetic acid comprising: (a) reaction of compound of formula (VIII) wherein Y is Cl, Br, I, OTs, OMs and R is C1-8 alkyl, benzyl, cycloalkyl, phenyl, substituted phenyl and their like; with a compound of formula (VIIIA) wherein M is K, Na or Li, preferably K; R1 is C1-4 alkyl, benzyl, C1-C8 cycloalkyl, phenyl and their like, in aqueous medium to give a compound of formula (IX) (b) cyclizing a compound of formula (IX) using a base to give a compound of formula (X) in a solvent. (c) hydrolyzing (X) using aqueous mineral acid.

Peptide Side-Arm Derivatives of Lariat Ethers and Bibracchial Lariat Ethers: Syntheses, Cation Binding Properties, and Solid State Structural Data

Aza-18-crown-6 and 4,13-diaza-18-crown-6 derivatives having one or two side arms have been prepared.The side arms are of the form >N-Gly-AA-OMe, where "AA" is an amino acid.The 18-membered ring compounds were prepared by alkylation of aza-18-crown-6 as follows: Gly-Gly-OMe (14, 57percent, mp 42-43 deg C); Gly-Ile-OMe (15, 50percent); Gly-Val-OMe (16, 56percent).Two-armed compounds were obtained by alkylation of 4,13-diaza-18-crown-6 as follows: Gly-Gly-OMe (18, 58percent, mp 118-119 deg C); Gly-Ala-OMe (19, 50percent, mp 62-63 deg C); Gly-Phe-OMe (20, 65percent, oil); Gly-Leu-OMe (21, 51percent, mp 72-73 deg C); Gly-Ile-OMe (22, 60percent, oil); Gly-Val-OMe (23, 59percent, oil).Sodium iodide complexes of 18, 19, and 20 were isolated.Solid state structural data are reported for 18 and its sodium complex, as well as its potassium complex that was reported in preliminary form (ref 9f).Compound 18 crystallizes in the triclinic space group P1 with cell constants a = 9.0210 (8), b= 10.4768 (15), and c = 15.357 (2) Angstroem, α = 87.457 (12) deg, β = 87.119 (10) deg, γ = 68.042 (9) deg, and Z = 2 for Dc = 1.286 g cm-3.Least-squares refinement based on 4034 observed reflections led to a final conventional R value of 0.041.The sodium iodide complex of 18 crystallizes in the monoclinic space group P21/c with cell constants a = 9.732 (3), b = 17.710 (2), and c = 38.848 (3) Angstroem, β = 96.99 (2) deg, and Z = 8 for Dc = 1.430 g cm-3.Least-squares refinement based on 5512 observed reflection led to a final conventional R value of 0.041.The potassium iodide complex of 18 crystallizes in the monoclinic space group C2/c with cell constans a = 15.656 (4), b = 14.752 (3), and c = 26.784 (3) Angstroem, β = 90.01 (2), and Z = 8 for Dc = 1.474 g cm-3.Least-squares refinement based on 2595 observed reflections led to a final conventional R value of 0.035.There are two crystallographically independent molecules in each of the three crystal structures.The sodium and potassium complexes are compared to other BiBLE complexes and to cryptates.Cation binding affinities for these compounds have been assessed in anhydrous methanol and are reported here for Na+ and K+ cations.