76983-50-1Relevant academic research and scientific papers
Synthesis of quinazolin-4-(3H)-ones from o-amidobenzonitriles using urea-hydrogen peroxide
Bandgar
, p. 2065 - 2068 (1997)
Synthesis of quinazolin-4-(3H)-ones from o-amido-benzonitriles has been carried out by using urea-hydrogen peroxide as a mild, stable and non- hazardous reagent.
Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst
Thorve, Pradip Ramdas,Maji, Biplab
, p. 1116 - 1124 (2021/02/26)
Herein, we report a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and anin situgenerated non-native secondary amine. The catalyst consists of ano-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.
Synthesis and photophysical property studies of the 2,6,8-triaryl-4- (phenylethynyl)quinazolines
Mphahlele, Malose Jack,Paumo, Hugues Kadem,El-Nahas, Ahmed M.,El-Hendawy, Morad M.
, p. 795 - 818 (2014/02/14)
The 2-Aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-Aryl-6,8- dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-Aryl-6,8-dibromo-4- (alkynyl)quinazoline
